Effect of hormone replacement therapy on vasomotor function of the coronary microcirculation in post-menopausal women with medically treated cardiovascular risk factors.
Effect of hormone replacement therapy on vasomotor function of the coronary microcirculation in post-menopausal women with medically treated cardiovascular risk factors.
复制标题
激素替代疗法对患有心血管危险因素的绝经后妇女冠状动脉微循环血管舒缩功能的影响。
DOI：
10.1093/eurheartj/ehp013
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发表时间：
2009
影响因子：
39.3
通讯作者：
Schelbert,HeinrichR
中科院分区：
文献类型：
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作者：
Schindler,ThomasH;Campisi,Roxana;Dorsey,Deborah;Prior,JohnO;Olschewski,Manfred;Sayre,James;Schelbert,HeinrichR
AimsThe的目的，这项研究的目的是评估影响激素替代疗法（HRT）对冠状动脉血管功能的绝经后妇女（PM）与药物治疗的心血管危险因素（RF）在一个横截面和纵向随访（FU）study.Methods和resultsMyocardial blood flow（MBF）responses to cold pressure testing（CPT）在绝经前妇女（CON）、有HRT和无HRT的PM中，以及在平均随访24 ± 14个月后的PM中，用正电子发射断层扫描（PET）测量绝经后引起的充血。与基线CON相比，有HRT和无HRT的PM患者MBF相对于CPT的内皮相关变化（ΔMBF）逐渐下降（0.35 ± 0.23 vs. 0.24 ± 0.20和0.16 ± 0.12 mL/g/min;P= 0.171和P = 0.021）。在未接受HRT的PM和基线时接受HRT但在FU期间停止HRT的患者中，FU时CPT的内皮相关ΔMBF显著低于基线时（0.05 ± 0.19 vs. 0.16 ± 0.12和−0.03 ± 0.14 vs. 0.25 ± 0.18 mL/g/min; P= 0.023和P = 0.001），而HRT对PM无显著影响（0.19 ± 0.22 vs.0.23 ± 0.22 mL/g/min;P= 0.453）。受损的充血性MBFs相比CON没有显着改变，从那些在基线examin.ConclusionLong-term管理的雌激素可能有助于维持内皮依赖性冠状动脉功能PM与药物治疗的心血管RF。
AimsThe aim of this study was to evaluate the effect of hormone replacement therapy (HRT) on coronary vasomotor function in post-menopausal women (PM) with medically treated cardiovascular risk factors (RFs) in a cross-sectional and a longitudinal follow-up (FU) study.Methods and resultsMyocardial blood flow (MBF) response to cold pressor testing (CPT) and during pharmacologically induced hyperaemia was measured with positron emission tomography in pre-menopausal women (CON), in PM with HRT and without HRT, and repeated in PM after a mean FU of 24 ± 14 months. When compared with CON at baseline, the endothelium-related change in MBF (ΔMBF) to CPT progressively declined in PM with HRT and without HRT (0.35 ± 0.23 vs. 0.24 ± 0.20 and 0.16 ± 0.12 mL/g/min;P= 0.171 andP= 0.021). In PM without HRT and in those with HRT at baseline but with discontinuation of HRT during FU, the endothelium-related ΔMBF to CPT was significantly less at FU than at baseline (0.05 ± 0.19 vs. 0.16 ± 0.12 and −0.03 ± 0.14 vs. 0.25 ± 0.18 mL/g/min;P= 0.023 andP= 0.001), whereas no significant change was observed in PM with HRT (0.19 ± 0.22 vs. 0.23 ± 0.22 mL/g/min;P= 0.453). Impaired hyperaemic MBFs when compared with CON were not significantly altered from those at baseline exam.ConclusionLong-term administration of oestrogen may contribute to maintain endothelium-dependent coronary function in PM with medically treated cardiovascular RFs.