ABNORMAL ESTROGEN-RECEPTOR IN CLINICAL BREAST-CANCER
ABNORMAL ESTROGEN-RECEPTOR IN CLINICAL BREAST-CANCER
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DOI：
10.1016/0960-0760(92)90214-4
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发表时间：
1992-09-01
影响因子：
4.1
通讯作者：
FUQUA, SAW
中科院分区：
文献类型：
--
作者：
MCGUIRE, WL;CHAMNESS, GC;FUQUA, SAW
我们在临床乳腺癌组织中发现了一些雌激素受体变异。我们有碱基对插入，过渡和删除外显子3,5和7。通过反激活试验，我们发现了具有非法功能的受体，包括在缺乏雌激素时转录活性的显性阳性受体和转录活性不高但阻止正常雌激素受体功能的显性阴性受体。
We have discovered a number of estrogen receptor variants in clinical breast cancer tissues. We have base-pair insertions, transitions, and deletions of exons 3, 5 and 7. Using a transactivation assay we have discovered receptors with outlaw function consisting of both dominant-positive receptors which are transcriptionally active in the absence of estrogen, and dominant-negative receptors which are transcriptionally inactive themselves but prevent normal estrogen receptor function.