Durability of antibody response to vaccination and surrogate neutralization of emerging variants based on SARS-CoV-2 exposure history.
Durability of antibody response to vaccination and surrogate neutralization of emerging variants based on SARS-CoV-2 exposure history.
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DOI：
10.1038/s41598-021-96879-3
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发表时间：
2021-08-30
影响因子：
4.6
通讯作者：
McNally EM
中科院分区：
文献类型：
--
作者：
McDade TW;Demonbreun AR;Sancilio A;Mustanski B;D'Aquila RT;McNally EM
针对严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）的两剂信使RNA疫苗在预防症状性COVID-19感染方面非常有效。然而，保护的持久性尚不清楚，对新出现的病毒变体的有效性也不清楚。此外，疫苗反应可能会因先前的SARS-CoV-2暴露史而有所不同。为了研究针对SARS-CoV-2变体的保护，我们测量了两种疫苗剂量后的结合和中和抗体应答。我们记录了疫苗接种后三个月抗体水平的显著下降，以及新出现的变异体的中和作用降低，强调需要确定临床保护的相关性，以告知加强疫苗接种的时机和适应症。
Two-dose messenger RNA vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are highly effective in preventing symptomatic COVID-19 infection. However, the durability of protection is not known, nor is the effectiveness against emerging viral variants. Additionally, vaccine responses may differ based on prior SARS-CoV-2 exposure history. To investigate protection against SARS-CoV-2 variants we measured binding and neutralizing antibody responses following both vaccine doses. We document significant declines in antibody levels three months post-vaccination, and reduced neutralization of emerging variants, highlighting the need to identify correlates of clinical protection to inform the timing of and indications for booster vaccination.
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DOI：
10.1056/nejmoa2034577
发表时间：
2020-12-31
期刊：
The New England journal of medicine
影响因子：
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10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
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作者：
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影响因子：
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