Studies on the orthogonal assembly of β-cyclodextrin-poly (ε-caprolactone) and ferrocene-poly (ethylene oxide)
Studies on the orthogonal assembly of β-cyclodextrin-poly (ε-caprolactone) and ferrocene-poly (ethylene oxide)
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DOI：
10.1016/j.carbpol.2012.11.001
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发表时间：
2013-02-15
影响因子：
11.2
通讯作者：
Wang Cai-Qi
中科院分区：
文献类型：
--
作者：
Jiang Ming-Wei;Guo Cheng-Gong;Wang Cai-Qi
将亲水性环状β-环糊精（β-CD）的宽侧选择性地接枝上具有柔性和疏水性的PCL臂，得到了一种具有“鱼状”结构的生物可降解多臂聚合物β-环糊精-聚己内酯（CD-PCL）。具有空腔和疏水性尾部的两亲性“水母状”聚合物在水溶液中可以基于末端疏水相互作用正交自组装成新型两亲性超分子共聚物CD-PCL/FcPEG，其聚环氧乙烷末端由二茂铁（FcPEG）修饰。用IR、NMR、UV等手段对CD-PCL和CD-PCL/FcPEG的化学结构进行了表征，并用透射电子显微镜（TEM）和动态光散射（DLS）研究了它们在水中的自组装结构。单独的CD-PCL在水中自组装成纳米囊泡，而CD-PCL/FcPEG成纳米球。用循环伏安法对超分子纳米球进行了进一步的研究。结果表明，嵌在超分子纳米球疏水核中的二茂铁基不能传递电子，也不能进行电化学氧化还原反应。(C)2012爱思唯尔有限公司保留所有权利。
A biodegradable multi-arm polymer beta-cyclodextrin-poly (epsilon-caprolactone) (CD-PCL) with a "jellyfish-like" structure was obtained, in which flexible and hydrophobic PCL arms were selectively grafted to the wide side of the hydrophilic torus-shaped beta-CD. The amphiphilic "jellyfish-like" polymer with a hollow cavity and hydrophobic tails could orthogonally self-assemble into a new amphiphilic supramolecular copolymer CD-PCL/FcPEG with poly (ethylene oxide) end-decorated by ferrocene (FcPEG) in aqueous solution based on terminal hydrophobic interactions. The chemical structures of CD-PCL and CD-PCL/FcPEG were characterized by IR, NMR and UV and their self-assembled structures in water were investigated by transmission electron microscopy (TEM) and dynamic light scattering (DLS). CD-PCL alone self-assembled into nano vesicles in water, while CD-PCL/FcPEG into nanospheres. The supramolecular nanospheres were further investigated by cyclic voltammogram. The results indicated that the ferrocenyl groups which were embedded into the hydrophobic core of the supramolecular nanospheres could not transmit electrons or carry out electrochemical oxidation and reduction reaction. (C) 2012 Elsevier Ltd. All rights reserved.