Linkage analysis between schizophrenia and index simple-sequence repeat loci for chromosome 21.
Linkage analysis between schizophrenia and index simple-sequence repeat loci for chromosome 21.
复制标题
精神分裂症与 21 号染色体索引简单序列重复基因座之间的连锁分析。
DOI：
10.1159/000154254
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发表时间：
1995
期刊：
影响因子：
1.8
通讯作者：
Coon,H
中科院分区：
文献类型：
--
作者：
Byerley,W;Hoff,M;Holik,J;Myles-Worsley,M;Waldo,M;Freedman,R;Coon,H
用7个高度多态的微卫星座位对9个精神分裂症多发家系进行了基因分型，构建了21号染色体的索引图谱。假设为常染色体显性遗传或隐性遗传，则没有发现连锁的证据。此外，非参数同胞对检验没有产生显著的连锁证据。
Nine multiplex schizophrenia families were genotyped with seven highly polymorphic microsatellite loci used in the construction of an index map of chromosome 21. Assuming either autosomal dominant or recessive transmission, evidence of linkage was not found. In addition, the nonparametric sib-pair test did not yield significant evidence of linkage.