Neuronal signalling of zinc: from detection and modulation to function.
Neuronal signalling of zinc: from detection and modulation to function.
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锌是一种必需的微量元素，它能稳定蛋白质结构，并对大量的酶、离子通道和神经递质受体进行变构调节。不稳定的锌（Zn2+）作为一种细胞内和细胞间的信号分子，对各种刺激作出反应，这在中枢神经系统中尤为重要。锌能神经元的特点是在突触小泡中有Zn2+沉积以及突触前Zn2+释放，它们存在于大脑皮层、海马体、杏仁核、嗅球和脊髓中。为了概述神经元中突触Zn2+和细胞内Zn2+信号传导，本文总结了用于检测Zn2+信号的荧光传感器、调节Zn2+信号产生和缓冲的细胞机制，以及它们对磷酸化信号传导、突触形成、突触可塑性以及感觉和认知功能的多效性影响的当前观点。
Zinc is an essential trace element that stabilizes protein structures and allosterically modulates a plethora of enzymes, ion channels and neurotransmitter receptors. Labile zinc (Zn2+) acts as an intracellular and intercellular signalling molecule in response to various stimuli, which is especially important in the central nervous system. Zincergic neurons, characterized by Zn2+ deposits in synaptic vesicles and presynaptic Zn2+ release, are found in the cortex, hippocampus, amygdala, olfactory bulb and spinal cord. To provide an overview of synaptic Zn2+ and intracellular Zn2+ signalling in neurons, the present paper summarizes the fluorescent sensors used to detect Zn2+ signals, the cellular mechanisms regulating the generation and buffering of Zn2+ signals, as well as the current perspectives on their pleiotropic effects on phosphorylation signalling, synapse formation, synaptic plasticity, as well as sensory and cognitive function.
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影响因子：
5.3
作者：
Bonanni, Laura;Chachar, Mushtaque;Jonas, Elizabeth A.
通讯作者：
Jonas, Elizabeth A.
影响因子：
16.2
作者：
Bossy-Wetzel, E;Talantova, MV;Lipton, SA
通讯作者：
Lipton, SA
影响因子：
4
作者：
Bozym, Rebecca A.;Thompson, Richard B.;Fierke, Carol A.
通讯作者：
Fierke, Carol A.
影响因子：
2.9
作者：
ANIKSZTEJN, L;CHARTON, G;BENARI, Y
通讯作者：
BENARI, Y
影响因子：
5.7
作者：
Budnik V;Salinas PC
通讯作者：
Salinas PC