Pathogenic roles of altered calcium channels and transporters in colon tumorogenesis
Pathogenic roles of altered calcium channels and transporters in colon tumorogenesis
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钙通道和转运蛋白改变在结肠肿瘤发生中的致病作用
DOI：
10.1016/j.lfs.2019.116909
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发表时间：
2019
期刊：
影响因子：
6.1
通讯作者：
Xu Jingyu
中科院分区：
文献类型：
--
作者：
Yang Xiaoxu;Lou Jun;Shan Weixi;Hu Yanxia;Du Qian;Liao Qiushi;Xie Rui;Xu Jingyu
胞浆内钙离子信号在多种细胞功能的调节中起着重要作用，钙通道/转运蛋白对调节细胞内钙稳态具有重要作用，钙稳态的异常可能导致包括结直肠癌（CRC）在内的多种肿瘤的发生。本文就[Ca 2 +]cytand Ca 2+通道/转运体如SOCE、TRP通道、SERCA和Na+/Ca 2+交换体在结直肠癌发生发展中的致病作用作一综述。了解[Ca 2 +]细胞因子CRC作用的详细分子机制对于开发Ca 2+通道/转运蛋白作为诊断和治疗靶点至关重要。以钙离子信号通路为靶点进行肿瘤治疗已成为一个新兴的研究领域，尽管目前对钙离子通道/转运体在肿瘤发生中的作用的认识还处于早期阶段，但我们仍然相信它们将作为新的预防/治疗靶点，具有潜在的广泛的临床意义。
Cytosolic calcium [Ca2+]cytsignaling plays a critical role in the regulation of multiple cellular functions, and Ca2+channels/transporters are important to regulate calcium homeostasis whose abnormality may contribute human tumorogenesis including colorectal cancer (CRC). In this review, we summarized and discussed the current knowledge on pathogenic roles of the altered [Ca2+]cytand Ca2+channels/transporters like SOCE, TRP channels, SERCA and Na+/Ca2+ exchangers in CRC tumorigenesis and progression. Understanding the detailed molecular mechanisms underlying the effects of [Ca2+]cyton CRC is essential to develop Ca2+channels/transporters as diagnostic and therapeutic targets. Targeting Ca2+signaling for cancer therapy has become an emerging research area nowadays, although our knowledge about the roles of Ca2+channels/transporters in tumorigenesis is still in the early stage, we still believe that they will act as novel preventive/therapeutic targets for CRC with potentially extensive clinical significance.