Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects:: case report
Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects:: case report
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DOI：
10.1016/j.jcms.2004.06.002
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发表时间：
2004-12-01
影响因子：
3.1
通讯作者：
Howaldt, HP
中科院分区：
文献类型：
--
作者：
Lendeckel, S;Jödicke, A;Howaldt, HP
本文报告一位7岁的otd女孩，在严重的头部外伤合并多块颅骨骨折后，接受去骨瓣减压术治疗难治性颅内高压，并将冷冻保存的颅骨碎片再植后，出现广泛的颅骨缺损。慢性感染导致颅骨不稳定，伴有明显的骨缺损。初次损伤后两年，颅骨缺损得到修复。由于从髂嵴可获得的自体松质骨的量有限，同时处理自体脂肪来源的干细胞，并在单个手术程序中应用于颅骨缺损。使用自体纤维蛋白胶将干细胞保持在原位。通过两个大的可吸收大孔片同时作为软组织屏障实现机械固定。术后过程顺利，CT扫描显示重建后3个月新骨形成和几乎完全的猫颈连续性。(C)2004年欧洲颅颌面外科协会。
This is a report of a 7-year-otd girl suffering from widespread calvarial defects after severe head injury with multifragment calvarial fractures, decompressive craniectomy for refractory intracranial hypertension and replantation of cryopreserved skull fragments.. Chronic infection resulted in an unstable skull with marked bony defects. Two years after the initial injury the calvarial defects were repaired. Due to the limited amount of autologous cancellous bone available from the iliac crest, autologous adipose derived stem cells were processed simultaneously and applied to the calvarial defects in a single operative procedure. The stem cells were kept in place using autologous fibrin glue. Mechanical fixation was achieved by two large, resorbable macroporous sheets acting as a soft tissue barrier at the same time. The postoperative course was uneventful and CT-scans showed new bone formation and near complete catvarial continuity three months after the reconstruction. (C) 2004 European Association for Cranio-MaxiHofacial Surgery.