Serglycin in human cancers.
Serglycin in human cancers.
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DOI：
10.5732/cjc.011.10314
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发表时间：
2011-09-01
影响因子：
--
通讯作者：
Qian, Chao-Nan
中科院分区：
文献类型：
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作者：
Li, Xin-Jian;Qian, Chao-Nan
丝甘肽属于具有Ser-Gly二肽重复序列的小蛋白聚糖家族，并且其被不同类型的糖胺聚糖侧链修饰。胞内丝甘肽通过与分泌颗粒中的蛋白酶、趋化因子或其他细胞因子物理结合来影响这些因子的保留和分泌。细胞外丝甘肽被发现由几种类型的人类癌细胞释放，并且它能够促进鼻咽癌细胞的转移。丝甘肽可以与CD 44结合，CD 44是位于细胞膜上的另一种糖蛋白。丝甘素促进癌细胞转移的作用依赖于其核心蛋白的糖基化，其糖基化可通过自分泌和旁分泌机制实现。进一步的研究是必要的，以阐明sergylycin信号传导机制，目标是靶向他们，以防止癌细胞转移。
Serglycin belongs to a family of small proteoglycans with Ser-Gly dipeptide repeats, and it is modified with different types of glycosaminoglycan side chains. Intracellular serglycin affects the retention and secretion of proteases, chemokines, or other cytokines by physically binding to these factors in secretory granules. Extracellular serglycin has been found to be released by several types of human cancer cells, and it is able to promote the metastasis of nasopharyngeal carcinoma cells. Serglycin can bind to CD44, which is another glycoprotein located in cellular membrane. Serglycin's function of promoting cancer cell metastasis depends on glycosylation of its core protein, which can be achieved by autocrine as well as paracrine secretion mechanisms. Further investigations are warranted to elucidate serglycin signaling mechanisms with the goal of targeting them to prevent cancer cell metastasis.