Decreased left ventricular stroke volume is associated with low-grade exercise tolerance in patients with chronic obstructive pulmonary disease.
Decreased left ventricular stroke volume is associated with low-grade exercise tolerance in patients with chronic obstructive pulmonary disease.
复制标题
慢性阻塞性肺部疾病患者的左心室中风体积减少与低度运动耐受性有关。
DOI：
10.1136/bmjresp-2016-000158
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发表时间：
2017
影响因子：
4.1
通讯作者：
Kubota I
中科院分区：
文献类型：
--
作者：
Inoue S;Shibata Y;Kishi H;Nitobe J;Iwayama T;Yashiro Y;Nemoto T;Sato K;Sato M;Kimura T;Igarashi A;Tokairin Y;Kubota I
慢性阻塞性肺疾病（COPD）患者的低运动耐量与预后不良相关。6分钟步行试验（6MWT）通常用于评估COPD患者的运动耐量。 然而，关于COPD患者的心功能和运动耐量之间的关系知之甚少。本研究的目的是确定稳定期COPD患者低水平运动耐量的心功能预测因素。我们招募了57例稳定期COPD患者（男性54例，女性3例）进行6MWT。排除了患有基础骨科疾病或心力衰竭的患者。通过超声心动图和对比增强心脏CT评价心功能。我们还测量了肺功能和6MWT距离。第一秒用力呼气量（FEV1）和百分预测FEV，沿着左心室舒张末期容积和左心室心输出量，通过心脏CT测量，与6MWT距离显着相关。 在多变量分析中，左心室每搏输出量是与6MWT中步行距离减少最密切相关的因素。在无心力衰竭的稳定期COPD患者中，左心室每搏输出量减少与低水平运动耐量相关。
Low-grade exercise tolerance is associated with a poor prognosis in patients with chronic obstructive pulmonary disease (COPD). The 6 min walk test (6MWT) is commonly used to evaluate exercise tolerance in patients with COPD. However, little is known regarding the relationship between cardiac function and exercise tolerance in patients with COPD. The aim of this study was to identify predictive factors in cardiac function for low-grade exercise tolerance in patients with stable COPD. We recruited 57 patients with stable COPD (men 54, women 3) to perform the 6MWT. Patients with underlying orthopaedic disease or heart failure were excluded. Cardiac function was evaluated by echocardiography and contrast-enhanced cardiac CT. We also measured pulmonary function and the 6MWT distance. Forced expiratory volume in 1 s (FEV1) and per cent predicted FEV, along with left ventricular end diastolic volume and left ventricular cardiac output as measured by cardiac CT, were significantly related to the 6MWT distance. On multivariate analysis, left ventricular stroke volume was the factor most closely associated with a decreased walked distance in the 6MWT. Decreased left ventricular stroke volume was associated with low-grade exercise tolerance in patients with stable COPD without heart failure.