Roles of DNA polymerase V and RecA protein in SOS damage-induced mutation.
Roles of DNA polymerase V and RecA protein in SOS damage-induced mutation.
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DOI：
10.1021/cr0404951
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发表时间：
2006-01
期刊：
影响因子：
62.1
通讯作者：
K. Schlacher;P. Pham;M. Cox;M. Goodman
中科院分区：
文献类型：
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作者：
K. Schlacher;P. Pham;M. Cox;M. Goodman
λ噬菌体DNA的损伤导致噬菌体在感染大肠杆菌时丧失活力。然而，如果细菌DNA在感染前因暴露于UV辐射而受损，则噬菌体活力恢复。这一过程被称为Weigle或W-再激活，伴随着λ中碱基替换突变数量的增加。1.对受损λ噬菌体的拯救和诱变是大肠杆菌DNA损伤诱导基因作用的副产物。coli中，作为SOS调节子的一部分表达。2-4更一般地，在与SOS诱导相关的染色体和附加型诱变中观察到的大幅增加（约100倍）被称为“SOS易错修复”。5
Damage to the DNA of bacteriophage λ results in a loss of phage viability upon infection ofEscherichia coli . However, phage viability is restored if the bacterial DNA is damaged prior to infection by exposure to UV radiation. This process, referred to as Weigle or W-reactivation, is accompanied by an increase in the number of base substitution mutations inλ.1 The rescue and mutagenesis of the damaged lambda phage is a byproduct of the action of DNA damageinducible genes inE. coli, expressed as part of the SOS regulon. 2-4 More generally, the large increase ( ∼100-fold) observed in both chromosomal and episomal mutagenesis associated with SOS induction is referred to as “SOS errorprone repair”. 5