Fine trabecularized carbon: Ideal material and texture for percutaneous device system of permanent left ventricular assist device
Fine trabecularized carbon: Ideal material and texture for percutaneous device system of permanent left ventricular assist device
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DOI：
10.1046/j.1525-1594.1998.06152.x
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发表时间：
1998-06-01
影响因子：
2.4
通讯作者：
Kormos, RL
中科院分区：
文献类型：
--
作者：
Tagusari, O;Yamazaki, K;Kormos, RL
经皮人工内脏系统的发展需要在外部环境和人体内部之间建立可靠的生物兼容连接。这对于永久性左心辅助装置的成功是必要的。然而，在表皮水平上寻找令人满意的界面已被证明是困难的。碳已经被提出用于这一应用，但它的质地通常不会促进周围组织的生长。因此，我们采用了一种新的加工方法来生产一种精细的小梁化碳植入物。该植入物的制备方法包括将低温热解碳渗透到用碳纤维包裹的碳芯的表面。这导致了紧密编织的碳多孔结构(碳纤维直径：35-50微米，最大孔径&200微米)，孔隙率从15%-75%逐渐增加。我们将测试样本经皮植入一头小牛体内进行组织学评估。植入后30d，表皮向下生长最少。显微镜分析显示，种植体周围有一层薄薄的纤维包膜，成熟的结缔组织和伴行的血管充满了细小的小梁化碳层的毛孔。根据这些结果，我们认为细小梁化碳非常适合于永久性左心室辅助装置中的经皮装置系统。
The development of a percutaneous artificial internal organ system requires a reliable biocompatible connection between the external environment and the inside of the human body. Such is necessary for the success of a permanent left ventricular assist device. However, the search for a satisfactory interface at the epidermal level has proven to be difficult. Carbon has been proposed for this application, but its texture does not typically promote ingrowth from surrounding tissue. We have therefore employed a new processing method to produce a fine trabecularized carbon implant. The method for preparing the implant involves infiltrating low temperature pyrolytic carbon into the surface of a carbon core which is wrapped with carbon fabric. This results in a tightly woven porous structure of carbon (carbon fiber diameter: 35-50 mu m, maximal pore size >200 mu m) with gradually increasing porosity from 15-75%. We implanted test samples percutaneously in a calf for in vivo histological evaluation. Thirty days after implantation epidermal downgrowth was minimal. Microscopic analysis revealed that a thin fibrous capsule surrounded the implant, and mature connective tissue with accompanying blood vessels filled the pores of the fine trabecularized carbon layer. From these results we suggest that fine trabecularized carbon is ideally suited for a percutaneous device system in a permanent left ventricular assist device.