Dietary habits and risk of ovarian cancer death in a large-scale cohort study (JACC study) in Japan
Dietary habits and risk of ovarian cancer death in a large-scale cohort study (JACC study) in Japan
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DOI：
10.1080/01635580701274178
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发表时间：
2007-01-01
影响因子：
2.9
通讯作者：
Tamakoshi, Akiko
中科院分区：
文献类型：
--
作者：
Sakauchi, Fumio;Khan, M. M. H.;Tamakoshi, Akiko
日本协作队列（JACC）研究成立于 1988-1990 年，由 46,465 名男性和 64,327 名女性组成，观察到 2003 年底。使用自我管理的食物频率问卷作为基线调查，并评估饮食习惯与卵巢癌死亡风险的关联，考虑到年龄、月经和生殖、人体测量、 和生活方式因素。观察期间，有77名女性死于卵巢癌。饮食因素的风险比通过考克斯比例风险模型计算。仅根据年龄进行调整，大量摄入干鱼或咸鱼和大白菜与卵巢癌死亡风险呈正相关，并且风险呈剂量依赖性增加。相反，豆腐的摄入量与风险呈负相关。在调整年龄和潜在混杂因素后，干鱼或咸鱼和大白菜摄入量的结果没有变化。然而，与摄入豆腐有关的重要性被削弱了。这项队列研究的结果表明，大量摄入干鱼或咸鱼和大白菜是卵巢癌死亡的潜在危险因素。然而，相比之下，大量摄入大豆豆腐（豆腐）可能对这种风险有预防作用。
The Japan Collaborative Cohort (JACC) Study was established in 1988-1990 and consisted of 46,465 men and 64,327 women observed until the end of 2003. A self-administered food frequency questionnaire was used as a baseline survey, and associations of dietary habits with the risk of ovarian cancer death were evaluated, taking into consideration age, menstrual and reproductive, anthropometric, and lifestyle factors. During the observation period, 77 women died of ovarian cancer. Hazard ratios for dietary factors were calculated by Cox's proportional hazards model. Being adjusted only for age, high intakes of dried or salted fish and Chinese cabbage were positively associated with the risk of ovarian cancer death, and the risk increased dose-dependently. In contrast, intake of soybean curd (tofu) was inversely associated with the risk. After being adjusted for age and potential confounding factors, the results regarding the intakes of dried or salted fish and Chinese cabbage did not change. However, the significance relating to the intake of soybean curd (tofu) was attenuated. Front the results of this cohort study, it was suggested that high intakes of dried or salted fish and Chinese cabbage were potential risk factors of ovarian cancer death. In contrast, however, a high intake of soy bean curd (tofu) might have preventive effects against the risk.