Tryptophan depletion and risk of depression relapse: A prospective study of tryptophan depletion as a potential predictor of depressive episodes
Tryptophan depletion and risk of depression relapse: A prospective study of tryptophan depletion as a potential predictor of depressive episodes
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DOI：
10.1016/s0006-3223(00)00893-3
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发表时间：
2000-08-15
影响因子：
10.6
通讯作者：
Delgado, PL
中科院分区：
文献类型：
--
作者：
Moreno, FA;Heninger, GR;Delgado, PL
背景资料：本研究探讨了色氨酸耗竭期间抑郁症状反应与未来抑郁发作之间的关系。方法：12例既往重度抑郁发作缓解且无药物治疗超过或等于3个月的受试者（患者）和12例匹配的健康（对照）受试者接受了两次色氨酸耗竭试验，间隔1周。在随访期间，汉密尔顿抑郁评定量表每周一次，持续1个月，每月一次，持续3个月，并在6个月和12个月，结果：从两个测试的结果，色氨酸耗竭具有78%的灵敏度，特异性80%，阳性预测值70%，阴性预测值86%，以确定未来的抑郁发作。生存分析表明，色氨酸耗竭的情绪反应可靠地预测了随访期间的重度抑郁发作（r =.2725，p =.014），结论：色氨酸耗竭可能在临床上有助于识别未来重度抑郁发作风险的个体，（C）2000年生物精神病学学会。
Background: This study investigated the relationship between depressive symptom response during tryptophan depletion and future depressive episodes,Methods: Twelve subjects with prior major depressive episodes in remission and medication-free for greater than or equal to 3 months (patients), and 12 matched healthy (control) subjects received two tryptophan depletion tests I week apart. During follow-up the Hamilton Depression Rating Scale was administered weekly for I month, monthly for 3 months, and once at 6 and 12 months,Results: With results from both tests, tryptophan depletion has a sensitivity of 78%, specificity of 80%, positive predictive value of 70%, and negative predictive value of 86% to identify future depressive episodes. Survival analysis shows that mood response to tryptophan depletion reliably predicts major depressive episodes during the follow-up year (r =.2725, p =.014),Conclusions: Tryptophan depletion may be clinically useful in identifying individuals at risk for future major depressive episodes, (C) 2000 Society of Biological Psychiatry.