Intracellular delivery of nano-formulated antituberculosis drugs enhances bactericidal activity
Intracellular delivery of nano-formulated antituberculosis drugs enhances bactericidal activity
复制标题
纳米抗结核药物的细胞内递送增强杀菌活性
DOI：
10.1002/jin2.27
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Donnellan S
中科院分区：
文献类型：
--
作者：
Donnellan S
结核病在全世界造成的死亡人数超过任何其他传染病。治疗需要长期（6 - 24个月）给予多种药物治疗。多药耐药菌株的出现是一个主要问题，并且在管道中几乎没有新药，迫切需要一种新的操作方法。固体药物纳米粒（SDNs）是纳米医学的一个新发展，为治疗提供了新的途径。在这里，我们表明SDNs在杀死致病性分枝杆菌方面比相同药物的水溶液形式更有效（50倍），并且可以靶向巨噬细胞内化的分枝杆菌，其中杆菌驻留。我们证明了双重和三重载药的SDNs的合成，促进了结核病的联合治疗。我们的研究结果表明，通过使用现有抗生素的SDNs，有可能改善药物递送，从而减少药物剂量，以减少副作用并对抗耐药性。
Tuberculosis kills more people worldwide than any other infectious disease. Treatment requires multiple drug therapy administered over long periods (6–24 months). The emergence of multidrug‐resistant strains is a major problem, and with few new drugs in the pipeline, a novel modus operandi is urgently required. Solid drug nanoparticles (SDNs), a new development in nanomedicine, offer a fresh therapeutic approach. Here, we show that SDNs are more effective (50‐fold) at killing pathogenic mycobacteria than aqueous forms of the same drug and can target mycobacteria internalised by macrophages, where bacilli reside. We demonstrate synthesis of dual and triple drug loaded SDNs, facilitating combination tuberculosis therapy. Our results suggest that by employing SDNs of existing antibiotics, it may be possible to improve drug delivery and therefore reduce drug dosage to lessen side effects and fight drug resistance.