AMPK and Placental Progenitor Cells
AMPK and Placental Progenitor Cells
复制标题
DOI：
10.1007/978-3-319-43589-3_4
复制
发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Brown, Thomas L.
中科院分区：
文献类型：
--
作者：
Kaufman, Melissa R.;Brown, Thomas L.
AMPK 在许多生理系统中都很重要，但在胚胎和胎盘发育中也起着至关重要的作用。胎盘是一个独特的器官，是怀孕和妊娠期间母亲和婴儿之间必不可少的生命线。在胎盘发育过程中，氧气浓度非常低，直到细胞分化建立适当的谱系，从而承担胎盘和胚胎生存所需的新功能。在此过程中平衡氧调节环境与能量需求和维持新陈代谢的需要，使 AMPK 处于维持胎盘细胞稳态的中心，因为它整合并响应众多复杂的刺激。 AMPK 在感知代谢和能量变化方面发挥着关键作用。一旦被激活，它就会打开产生能量的途径并关闭分解代谢过程。 AMPK 协调细胞生长、分化和营养物质运输以维持细胞存活。 AMPK 的适当调节对于正常胎盘和胚胎发育至关重要，其失调可能导致妊娠相关疾病，如宫内生长受限、胎盘功能不全或先兆子痫。
AMPK is important in numerous physiological systems but plays a vital role in embryonic and placental development. The placenta is a unique organ that is the essential lifeline between the mother and baby during pregnancy and gestation. During placental development, oxygen concentrations are very low until cells differentiate to establish the appropriate lineages that take on new functions required for placental and embryonic survival. Balancing the oxygen regulatory environment with the demands for energy and need to maintain metabolism during this process places AMPK at the center of maintaining placental cellular homeostasis as it integrates and responds to numerous complex stimuli. AMPK plays a critical role in sensing metabolic and energy changes. Once activated, it turns on pathways that produce energy and shuts down catabolic processes. AMPK coordinates cell growth, differentiation, and nutrient transport to maintain cell survival. Appropriate regulation of AMPK is essential for normal placental and embryonic development, and its dysregulation may lead to pregnancy-associated disorders such as intrauterine growth restriction, placental insufficiency, or preeclampsia.