AUDITORY PATHWAY AND AUDITORY ACTIVATION OF PRIMARY VISUAL TARGETS IN THE BLIND MOLE RAT (SPALAX-EHRENBERGI) .1. 2-DEOXYGLUCOSE STUDY OF SUBCORTICAL CENTERS
AUDITORY PATHWAY AND AUDITORY ACTIVATION OF PRIMARY VISUAL TARGETS IN THE BLIND MOLE RAT (SPALAX-EHRENBERGI) .1. 2-DEOXYGLUCOSE STUDY OF SUBCORTICAL CENTERS
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DOI：
10.1002/cne.902840209
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发表时间：
1989-06-08
影响因子：
2.5
通讯作者：
WOLLBERG, Z
中科院分区：
文献类型：
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作者：
BRONCHTI, G;HEIL, P;WOLLBERG, Z
盲鼹鼠Spalax ehrenbergi是一种地下啮齿动物，对化石生活表现出惊人的行为、结构和生理适应能力，包括高度退化的眼睛和视神经，以及表明低频听力高度专门化的行为听力图。结合Nissl/Kluver-Barrera染色材料，2-脱氧葡萄糖功能图谱结合Nissl/Kluver-Barrera染色材料，揭示了典型的哺乳动物听觉通路，以及一些空间化低频听力的迹象，如上橄榄复合体中存在分化较差的外侧核和发育良好的内侧核。最引人注目的发现是在有视力的啮齿类动物的背侧膝状体和对应于视觉区域的皮质区域有明显的2-脱氧葡萄糖标记。这些结果为研究天然神经可塑性和代偿提供了一个很好的模型系统。在这份报告中，我们将自己限制在皮质下水平。大脑皮层水平将在下面的论文中全面讨论。
The blind mole rat Spalax ehrenbergi is a subterranean rodent that shows striking behavioral, structural, and physiological adaptations to fossorial life including highly degenerated eyes and optic nerves and a behavioral audiogram that indicates high specialization for low-frequency hearing. A 2-deoxyglucose functional mapping of acoustically activated structures, in conjunction with Nissl/Kluver-Barrera-stained material, revealed a typical mammalian auditory pathway with some indications for spacialized low-frequency hearing such as a poorly differentiated lateral nucleus and a well-developed medial nucleus in the superior olive complex. The most striking finding was a marked 2-deoxyglucose labeling of the dorsal lateral geniculate body and of cortical regions that correspond to visual areas in sighted rodents. The results render the blind mole rat a good model system for studying natural neural plasticity and intermodal compensation. In this report, we confine ourselves to the subcortical levels. The cortical level will be dealt comprehensively in a following paper.