INTERACTION OF POLY-UNSATURATED FATTY-ACIDS WITH ANIMAL-CELLS AND ENVELOPED VIRUSES
INTERACTION OF POLY-UNSATURATED FATTY-ACIDS WITH ANIMAL-CELLS AND ENVELOPED VIRUSES
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DOI：
10.1128/aac.18.6.962
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发表时间：
1980-01-01
影响因子：
4.9
通讯作者：
INBAR, M
中科院分区：
文献类型：
--
作者：
KOHN, A;GITELMAN, J;INBAR, M
必需的不饱和脂肪酸，如油酸、亚油酸或花生四烯酸，被掺入动物细胞的磷脂中，并诱导细胞膜流动性的变化。将包膜病毒（例如虫病毒、粘病毒、副粘病毒或疱疹病毒）暴露于微摩尔浓度的这些脂肪酸（对动物细胞无毒）会导致这些病毒的感染性迅速丧失。脑心肌炎病毒、脊髓灰质炎病毒或SV40等裸病毒不受亚油酸孵育的影响。正如在电子显微镜中观察到的那样，感染性的丧失归因于这些病毒粒子的脂蛋白包膜的破坏。
Essential unsaturated fatty acids such as oleic, linoleic or arachidonic were incorporated into the phospholipids of animal cells and induced in them a change in the fluidity of their membranes. Exposure of enveloped viruses such as arbo-, myxo-, paramyxo- or herpesviruses to micromolar concentrations of these fatty acids (which are not toxic to animal cells) caused rapid loss of infectivity of these viruses. Naked viruses such as encephalomyocarditis virus, poliovirus or SV40 were not affected by incubation with linoleic acid. The loss of infectivity was attributed to a disruption of the lipoprotein envelope of these virions, as observed in an electron microscope.