The cell biology of neural stem and progenitor cells and its significance for their proliferation versus differentiation during mammalian brain development
The cell biology of neural stem and progenitor cells and its significance for their proliferation versus differentiation during mammalian brain development
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DOI：
10.1016/j.ceb.2008.09.008
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发表时间：
2008-12-01
影响因子：
7.5
通讯作者：
Huttner, Wieland B.
中科院分区：
文献类型：
--
作者：
Farkas, Lilla M.;Huttner, Wieland B.
神经干细胞和神经前体细胞在发育过程中从增殖到分化的转换是决定大脑大小的关键因素。这种转换与神经干细胞和神经前体细胞的两个主要类别的结构密切相关，即顶端(神经上皮，放射状胶质)和基础(中间)前体细胞，这反过来对它们的对称和不对称分裂至关重要。围绕啮齿动物新皮质的发育，我们讨论了在理解顶端和基底层祖细胞的细胞生物学方面的最新进展，将关键的调节分子置于亚细胞环境中，并强调它们在控制增殖和分化中的作用。
The switch of neural stem and progenitor cells from proliferation to differentiation during development is a crucial determinant of brain size. This switch is intimately linked to the architecture of the two principal classes of neural stem and progenitor cells, the apical (neuroepithelial, radial glial) and basal (intermediate) progenitors, which in turn is crucial for their symmetric versus asymmetric divisions. Focusing on the developing rodent neocortex, we discuss here recent advances in understanding the cell biology of apical and basal progenitors, place key regulatory molecules into subcellular context, and highlight their roles in the control of proliferation versus differentiation.