The cross-generational mother-daughter-aunt-niece design: establishing validity of the MDAN design with NLSY fertility variables.

The cross-generational mother-daughter-aunt-niece design: establishing validity of the MDAN design with NLSY fertility variables.
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DOI:
10.1007/s10519-008-9225-0
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发表时间:
2008-11
期刊:
影响因子:
2.6
通讯作者:
Miller, Warren B.
Miller, Warren B.
中科院分区:
医学3区
文献类型:
--
作者:
Rodgers, Joseph Lee;Bard, David E.;Johnson, Amber;D'Onofrio, Brian;Miller, Warren B.

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使用全国青年纵向调查(NLSY)生育变量,我们介绍并说明了一种新的遗传信息设计。首先,我们开发了一个亲属关系链接算法,使用NLSY 79和NLSY-Children数据将母亲与女儿和阿姨与侄女联系起来。然后,我们构建母女相关性进行比较,阿姨侄女的相关性,MDAN设计,在定量遗传模型的背景下。我们的实证说明使用DF分析和广义估计方程(GEE)来估计NLSY-Children数据集中NLSY 79姐妹对及其孩子的生物统计参数,其结果提供了表面有效性和并发有效性,以支持设计的功效。我们描述扩展的MDAN设计。与大多数行为遗传学研究中采用的典型代内设计相比,本设计的跨代特征具有一定的优势和有趣的特点。特别是,我们注意到,传统的生物统计模型的平等环境假设的跨代设计的背景下转移。这些转变提出了问题,并为未来使用MDAN和其他跨代设计的研究提供了动力。
Using National Longitudinal Survey of Youth (NLSY) fertility variables, we introduce and illustrate a new genetically-informative design. First, we develop a kinship linking algorithm, using the NLSY79 and the NLSY-Children data to link mothers to daughters and aunts to nieces. Then we construct mother–daughter correlations to compare to aunt–niece correlations, an MDAN design, within the context of the quantitative genetic model. The results of our empirical illustration, which uses DF Analysis and generalized estimation equations (GEE) to estimate biometrical parameters from NLSY79 sister–sister pairs and their children in the NLSY-Children dataset, provide both face validity and concurrent validity in support of the efficacy of the design. We describe extensions of the MDAN design. Compared to the typical within-generational design used in most behavior genetic research, the cross-generational feature of this design has certain advantages and interesting features. In particular, we note that the equal environment assumption of the traditional biometrical model shifts in the context of a cross-generational design. These shifts raise questions and provide motivation for future research using the MDAN and other cross-generational designs.
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发表时间: 2007-01-01
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