Origin and function of cartilage stem/progenitor cells in osteoarthritis.
Origin and function of cartilage stem/progenitor cells in osteoarthritis.
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DOI：
10.1038/nrrheum.2014.200
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发表时间：
2015-04
期刊：
影响因子：
--
通讯作者：
Tuan RS
中科院分区：
文献类型：
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作者：
Jiang Y;Tuan RS
关节软骨是一种生理上不能自我更新的无血管组织，具有单一细胞类型软骨细胞，其功能是关节关节的承重面。软骨损伤通常在时空上从关节表面进展到软骨下骨，导致退行性关节疾病的发展，如骨关节炎（OA）。尽管缺乏内在的修复能力，关节软骨已被证明含有干细胞或祖细胞群，类似于在许多其他成人组织中发现的干细胞或祖细胞，被认为参与组织稳态的维持。这些所谓的软骨源性干细胞/祖细胞（CSPCs）已经在人、马和牛关节软骨中被观察到，并根据干细胞相关表面标记物的表达、克隆性和多系分化能力被鉴定、分离和表征。然而，CSPCs的起源和功能尚不完全清楚。我们在此综述CSPC细胞的研究现状，并讨论这些细胞的可能来源，它们在软骨修复中的作用，以及它们在OA中的治疗潜力。
Articular cartilage is a physiologically non-self-renewing avascular tissue with a singular cell type, the chondrocyte, which functions as the load-bearing surface of the arthrodial joint. Injury to cartilage often progresses spatiotemporally from the articular surface to the subchondral bone, leading to development of degenerative joint diseases such as osteoarthritis (OA). Although lacking intrinsic reparative ability, articular cartilage has been shown to contain a population of stem cells or progenitor cells, similar to those found in many other adult tissues, that are thought to be involved in the maintenance of tissue homeostasis. These so-called cartilage-derived stem/progenitor cells (CSPCs) have been observed in human, equine and bovine articular cartilage, and have been identified, isolated and characterized on the basis of expression of stem-cell-related surface markers, clonogenicity and multilineage differentiation ability. However, the origin and functions of CSPCs are incompletely understood. We review here the current status of CSPC research and discuss the possible origin of these cells, what role they might have in cartilage repair, and their therapeutic potential in OA.