INTERLEUKIN-8 (IL-8) - THE MAJOR NEUTROPHIL CHEMOTACTIC FACTOR IN THE LUNG
INTERLEUKIN-8 (IL-8) - THE MAJOR NEUTROPHIL CHEMOTACTIC FACTOR IN THE LUNG
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DOI：
10.3109/01902149109063278
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发表时间：
1991-01-01
影响因子：
1.7
通讯作者：
STRIETER, RM
中科院分区：
文献类型：
--
作者：
KUNKEL, SL;STANDIFORD, T;STRIETER, RM
许多新的趋化性细胞因子越来越被认为是从外周血中诱导特异性炎症细胞到炎症部位的重要参与者。 最近的观察表明，某些趋化细胞因子对单个免疫/炎症细胞群的选择性运动具有特异性。 研究较多的趋化细胞因子之一是鉴定为白细胞介素-8（IL-8）的中性粒细胞趋化因子。 这种多肽介质由单核吞噬细胞以及许多非炎性细胞大量产生。 后一列表包括成纤维细胞和上皮细胞。 此外，成纤维细胞和上皮细胞合成IL-8涉及刺激特异性，因为非炎性细胞产生这种介质依赖于初始宿主反应。 在肺的情况下，肺泡巨噬细胞似乎通过产生因子如白细胞介素-1和肿瘤坏死因子发挥中心作用，所述因子是肺成纤维细胞和II型上皮细胞诱导IL-8的有效刺激物。 级联样相互作用可导致肺快速产生大量的IL-8，并可选择性地将中性粒细胞募集到肺动脉和/或肺泡。 这一系列的事件，导致细胞因子网络在肺中，可能是一个重要的现象，产生一个主要的趋化因子重要的各种肺部疾病。
A number of novel chemotactic cytokines are becoming increasingly recognized as important participants in the elicitation of specific inflammatory cells from the peripheral blood to sites of inflammation. Recent observations have now demonstrated that certain chemotactic cytokines possess specificity for the selected movement of individual immune/inflammatory cell populations. One of the more studied chemotactic cytokines is a neutrophil chemotactic factor identified as interleukin-8 (IL-8). This polypeptide mediator is produced in abundance by mononuclear phagocytic cells, as well as a number of non-inflammatory cells. This latter list includes both fibroblasts and epithelial cells. Moreover, the synthesis of IL-8 by fibroblasts and epithelial cells involves stimulus specificity, as the production of this mediator by non-inflammatory cells is dependent upon an initial host response. In the context of the lung, the alveolar macrophage appears to play a central role by generating factors, such as interleukin-1 and tumor-necrosis factor, which are potent stimuli for the induction of IL-8 by the lung fibroblasts and type II epithelial cells. The cascade-like interaction may lead to the rapid production of significant quantities of IL-8 by the lung and may selectively recruit neutrophils to the pulmonary interstitium and/or airspace. This sequence of events, which leads to cytokine networking in the lung, may be an important phenomenon for the generation of a major chemotaxin important to a variety of lung diseases.