Cluster Headache Attacks Treated for up to Three Months with Subcutaneous Sumatriptan (6 mg)
Cluster Headache Attacks Treated for up to Three Months with Subcutaneous Sumatriptan (6 mg)
复制标题
使用皮下注射舒马曲坦（6 毫克）治疗丛集性头痛发作长达三个月
DOI：
10.1046/j.1468-2982.1995.1505446.x
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发表时间：
1995
期刊：
影响因子：
4.9
通讯作者：
G. ]. Micelli G [corrected to Micieli
中科院分区：
文献类型：
--
作者：
K. Ekbom;A. Krabbe;G. Micieli;A. Prusiński;J. Cole;A. Pilgrim;D. Noronha;G. ]. Micelli G [corrected to Micieli
在一项为期24个月的开放式研究的前三个月中，评估了皮下注射舒马曲坦6毫克对丛集性头痛的长期急性治疗的安全性和有效性，138名患者每天最多用一次6毫克注射治疗两次发作。总共处理了6353起袭击事件。在舒马曲坦治疗的发作中，28%的不良事件与偏头痛长期试验中的不良事件定性上相似。频繁使用舒马曲坦并不会增加其发病率。在生命体征、心电记录或实验室参数方面没有临床显著的治疗效果。头痛缓解(从非常严重、重度或中度疼痛到轻度或无疼痛)在15分钟内获得缓解，治疗的中位数为96%。没有迹象表明有快速反应、反应速度降低或长期治疗后发作频率增加。本研究表明，长期皮下应用舒马曲坦6 mg是治疗丛集性头痛的一种耐受性良好且有效的急性治疗方法。
In the first three months of a 24-month open study to assess the safety and efficacy of subcutaneous sumatriptan 6 mg in the long-term acute treatment of cluster headache, 138 patients treated a maximum of two attacks daily each with a single 6 mg injection. A total of 6353 attacks were treated. Adverse events, reported in 28% of sumatriptan-treated attacks, were qualitatively similar to those seen in migraine long-term trials. Their incidence did not increase with frequent use of sumatriptan. There were no clinically significant treatment effects on vital signs, ECG recordings or laboratory parameters. Headache relief (a reduction from very severe, severe or moderate pain to mild or no pain) at 15 min was obtained for a median of 96% of attacks treated. There was no indication of tachyphylaxis, decrease in the speed of response, or increased frequency of attacks with long-term treatment. This study demonstrated that, in long-term use, subcutaneous sumatriptan 6 mg is a well-tolerated and effective acute treatment for cluster headache.