Combined segregation and linkage analysis of 59 Hodgkin's disease families indicates the role of HLA determinants.
Combined segregation and linkage analysis of 59 Hodgkin's disease families indicates the role of HLA determinants.
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对 59 个霍奇金病家族的组合分离和连锁分析表明了 HLA 决定簇的作用。
DOI：
10.1038/sj.ejhg.5200419
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Collins,A
中科院分区：
文献类型：
--
作者：
Shugart,YY;Collins,A
通过文献检索，我们确定了共59个核心家庭与霍奇金病（HD）。这些家庭中的受影响的个人HLA单倍型。为了评估HD的HLA连锁决定因素的作用，并调查家族性HD的遗传模式，进行了分离和连锁分析，以及同胞对的半参数分析。在单基因座模型中，一般单基因座模型与加性模型相比没有改善。然而，两个位点的加性模型给出了最佳的整体拟合和3.55的lod得分。我们的结论是，HD是最有可能决定的HLA相关的主要基因和其他非HLA遗传因素与环境的影响。
Through a literature search, we identified a total of 59 nuclear families with Hodgkin's disease (HD). The affected individuals in these families were HLA haplotyped. To evaluate the role of HLA-linked determinants of HD and investigate the mode of inheritance of familial HD, a combined segregation and linkage analysis was performed, together with a semi-parametric analysis of sib pairs. Amongst single locus models, a general single locus model showed no improvement over an additive model. However, a two locus additive model gave the best overall fit and a lod score of 3.55. We conclude that HD is most likely to be determined by both an HLA-associated major gene and other non-HLA genetic factors together with environmental effects.