Cerebrovascular reactivity and cerebral autoregulation in normal subjects
Cerebrovascular reactivity and cerebral autoregulation in normal subjects
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DOI：
10.1016/j.jns.2009.06.041
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发表时间：
2009-10-15
影响因子：
4.4
通讯作者：
Marshall, Randolph S.
中科院分区：
文献类型：
--
作者：
Carrera, Emmanuel;Lee, Leslie K.;Marshall, Randolph S.
背景：临床上使用CO2激发的脑血管反应性（CVR）测试作为脑血管储备的测量。目的：通过连续监测脑血流速度（CBFV）和动脉血压（ABP），比较健康志愿者CVR和CA的差异。使用吸入5%CO2后的平均CBFV变化评估CVR。结果：吸入CO2后，自发性ABP和CBFV之间的相位差从37.9 ± 13.8度下降到21.0 ± 7.2度（P <0.05），而在0.1Hz时，自发性ABP和CBFV之间的相位差从37.9 ± 13.8度下降到21.0 ± 7.2度（P <0.05），而在0.1Hz时，自发性ABP和CBFV之间的相位差从37.9 ± 13.8度下降到21.0 ± 7.2度（P <0.05）。
Background: Cerebrovascular reactivity (CVR) testing with CO2 challenge is used clinically as a measure of cerebrovascular reserve. However it is not known whether CVR measures the same physiological process as spontaneous cerebral autoregulation (CA).Purpose: To compare CVR with CA in healthy Volunteers, using continuous monitoring of cerebral blood flow velocity (CBFV) and arterial blood pressure (ABP).Methods: We prospectively studied CVR and CA in 18 healthy volunteers. CVR was assessed using mean CBFV changes after 5% CO2 inhalation. CA was determined by transfer function analysis to derive the phase shift between spontaneous ABP and CBFV fluctuations at 0.1 Hz.Results: CO2 inhalation produced a significant decrease in phase shift from 37.9 +/- 13.8 degrees to 21.0 +/- 7.2 degrees (p