Determinants of 24-hour urinary oxalate excretion
Determinants of 24-hour urinary oxalate excretion
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DOI：
10.2215/cjn.01410308
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发表时间：
2008-09-01
影响因子：
9.8
通讯作者：
Curhan, Gary C.
中科院分区：
文献类型：
--
作者：
Taylor, Eric N.;Curhan, Gary C.
背景和目的：高水平的尿草酸盐显著增加草酸钙肾结石的风险。然而，尿草酸排泄的决定因素尚不清楚。目的是研究饮食因素、年龄、体型、糖尿病和尿因素对24小时尿草酸盐的影响。设计、设置、参与者和测量：我们对3348名结石形成和非结石形成的参与者进行了一项横断面研究，这些参与者参加了卫生专业人员随访研究（男性），护士健康研究结果：男性尿草酸盐中位数为39 mg/d，老年女性为27 mg/d，年轻女性为26 mg/d。饮食中草酸含量最高的四分位数的参与者比最低四分位数的参与者排出的尿草酸多1.7 mg/d（P趋势0.001）。饮食和尿草酸之间的关系是类似的个人与肾结石。每天摄入1000毫克或更多维生素C的参与者比每天摄入1000毫克或更多维生素C的参与者排出的尿草酸盐多6.8毫克
Background and objectives: Higher levels of urinary oxalate substantially increase the risk of calcium oxalate kidney stones. However, the determinants of urinary oxalate excretion are unclear. The objective was to examine the impact of dietary factors, age, body size, diabetes, and urinary factors on 24-h urinary oxalate.Design, setting, participants, and measurements: We conducted a cross-sectional study of 3348 stone forming and nonstone-forming participants in the Health Professionals Follow-up Study (men), the Nurses' Health Study (older women), and the Nurses' Health Study 11 (younger women).Results: Median urinary oxalate was 39 mg/d in men, 27 mg/d in older women, and 26 mg/d in younger women. Participants in the highest quartile of dietary oxalate excreted 1.7 mg/d more urinary oxalate than participants in the lowest quartile (P trend 0.001). The relation between dietary and urinary oxalate was similar in individuals with and without nephrolithiasis. Participants consuming 1000 mg/d or more of vitamin C excreted 6.8 mg/d more urinary oxalate than participants consuming