Environmental Polychlorinated Biphenyl Exposure and Breast Cancer Risk: A Meta-Analysis of Observational Studies.
Environmental Polychlorinated Biphenyl Exposure and Breast Cancer Risk: A Meta-Analysis of Observational Studies.
复制标题
环境多氯联苯暴露与乳腺癌风险：观察研究的荟萃分析。
DOI：
10.1371/journal.pone.0142513
复制
发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Wu K
中科院分区：
文献类型：
--
作者：
Zhang J;Huang Y;Wang X;Lin K;Wu K
多氯联苯（PCB）暴露与乳腺癌风险之间的关系已被广泛研究，但结果仍存在争议。我们进行了一项荟萃分析，以评估PCB暴露和乳腺癌风险的观察性研究的证据。截至2014年11月，从PubMed、EMBASE、CBM和CNKI数据库中识别出了含有PCB体内剂量数据的相关研究。采用多变量调整比值比（OR）和95%置信区间（CI）评估PCB暴露与乳腺癌风险之间的关系。同时进行异质性检验、敏感性分析、亚组分析和发表偏倚检验。为了进一步探讨特定组的PCB同系物和乳腺癌之间的关联，我们检查了PCB同系物分类，根据其结构，生物学和药代动力学特性，第一组（潜在的雌激素），第二组（潜在的抗雌激素和免疫毒性，二恶英样），和第三组（苯巴比妥，CYP 1A和CYP 2B诱导剂，生物持久性）。在筛选的660项研究中，选择了25项符合标准的研究，共涉及来自8个国家的12866名参与者（6088例病例和6778例对照）。结果表明，乳腺癌的风险与第二组有关（OR = 1.23，95%CI：1.08-1.40）和III组（OR = 1.25，95%CI：1.09-1.43），但与I组（OR = 1.10，95%CI：0.97-1.24）PCB或PCB总暴露（OR = 1.09，95%CI：0.97-1.22）无关。我们基于选定研究的荟萃分析发现，第二组和第三组PCB暴露可能会导致乳腺癌的风险。需要在多氯联苯含量较高的发展中国家开展更多的研究，并开展研究，探讨有机氯化合物混合物与乳腺癌风险之间的关系。
Association between polychlorinated biphenyl (PCB) exposure and breast cancer risk has been widely studied, but the results remain controversial. We performed a meta-analysis to evaluate the evidences from observational studies on PCB exposure and breast cancer risk. Relevant studies with data on internal PCB dose were identified from PubMed, EMBASE, CBM and CNKI databases through November 2014. Multivariable-adjusted odds ratio (OR) with 95% confidence intervals (CIs) were applied to assess the association between PCB exposure and breast cancer risk. Heterogeneity test, sensitivity analysis, subgroup analysis and publication bias test were also performed. To further explore the association between specific groups of PCB congeners and breast cancer, we examined the PCB congeners classified, according to their structural, biological and pharmacokinetics properties, as group I (potentially estrogenic), group II (potentially anti-estrogenic and immunotoxic, dioxin-like), and group III (phenobarbital, CYP1A and CYP2B inducers, biologically persistent). Of 660 studies screened, 25 studies which met criteria were selected, involving a total of 12866 participants (6088 cases and 6778 controls) from eight countries. The results showed that the risk of breast cancer was associated with group II (OR = 1.23, 95% CI: 1.08–1.40) and group III (OR = 1.25, 95% CI: 1.09–1.43) PCBs, but not with group I (OR = 1.10, 95%CI: 0.97–1.24) PCBs or total PCB exposure (OR = 1.09, 95%CI: 0.97–1.22). Our meta-analysis based on the selected studies found group II and group III PCB exposure might contribute to the risk of breast cancer. More studies in developing countries with higher PCB levels are needed, as well as studies to explore the relationships between mixtures of organochlorine compounds and breast cancer risk.