Macrophages, lipoprotein metabolism, and atherosclerosis: insights from murine bone marrow transplantation studies.
Macrophages, lipoprotein metabolism, and atherosclerosis: insights from murine bone marrow transplantation studies.
复制标题
巨噬细胞、脂蛋白代谢和动脉粥样硬化：来自小鼠骨髓移植研究的见解。
DOI：
10.1097/00041433-199904000-00003
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发表时间：
1999
影响因子：
4.4
通讯作者：
Fazio,S
中科院分区：
文献类型：
--
作者：
Linton,MF;Fazio,S
巨噬细胞表达多种可能有助于脂蛋白代谢和动脉粥样硬化病变形成的基因。使用基因靶向小鼠作为供体和受体的骨髓移植实验提供了一种有用的方法来检查巨噬细胞基因表达对体内脂蛋白代谢和动脉粥样硬化形成的贡献。本文介绍了从小鼠骨髓移植研究中获得的载脂蛋白 E 和 LDL 受体巨噬细胞表达作用的最新见解。
The macrophage expresses a variety of genes that may contribute to lipoprotein metabolism and atherosclerotic lesion formation. Bone marrow transplantation experiments using gene-targeted mice, both as donors and recipients, provide a useful approach to examine the contribution of macrophage gene expression to lipoprotein metabolism and atherogenesis in vivo. This article describes recent insights into the role of macrophage expression of apolipoprotein E and the LDL receptor gained from bone marrow transplantation studies in the mouse.