Serum cytokines correlated with the disease severity of generalized pustular psoriasis
Serum cytokines correlated with the disease severity of generalized pustular psoriasis
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DOI：
10.1155/2013/702763
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发表时间：
2013-01-01
期刊：
影响因子：
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通讯作者：
Yamanishi, Kiyofumi
中科院分区：
文献类型：
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作者：
Yamamoto, Masaaki;Imai, Yasutomo;Yamanishi, Kiyofumi
为了表征反映泛发性脓疱型银屑病（GPP）严重程度的血清生物标志物，我们在疾病过程中检测了6例GPP患者的39份血清样本中多种细胞因子/趋化因子水平。血清IL-4、IL-8、CXCL 1和CCL 3水平与GPP严重程度评分、白色细胞计数和血清C反应蛋白水平呈正相关。血清IL-1 β、IL-1 ra、IL-6、IL-10、IL-12 p70、IL-18、IL-22、IFN-γ和VEGF水平与上述3项临床指标均呈显著正相关（r > 0.4，p < 0.01）。其中，IL-10和IL-22在治疗后与GPP评分平行显著降低，因此这两种血清细胞因子可能有助于评估GPP治疗的疗效。
To characterize serum biomarkers reflecting the severity of generalized pustular psoriasis (GPP), we measured multiple cytokine/chemokine levels in 39 serum samples from 6 cases with GPP during the course of the disease. Serum levels of IL-4, IL-8, CXCL1 and CCL3 were positively correlated with the severity scores of GPP, white blood cell counts and serum C-reactive protein levels. Serum levels of IL-1 beta, IL-1ra, IL-6, IL-10, IL-12p70, IL-18, IL-22, IFN-gamma and VEGF showed strong positive correlations (r > 0.4, p < 0.01) with all those 3 clinical markers. Of those, IL-10 and IL-22 were significantly decreased after treatment in parallel with the GPP score and therefore those two serum cytokines might be useful to evaluate the efficacy of treatment for GPP.