REBOUND EXCITATION OF SMOOTH MUSCLE CELLS OF GUINEA-PIG TAENIA COLI AFTER STIMULATION OF INTRAMURAL INHIBITORY NERVES
REBOUND EXCITATION OF SMOOTH MUSCLE CELLS OF GUINEA-PIG TAENIA COLI AFTER STIMULATION OF INTRAMURAL INHIBITORY NERVES
复制标题
DOI：
10.1113/jphysiol.1966.sp007975
复制
发表时间：
1966-01-01
影响因子：
5.5
通讯作者：
BENNETT, MR
中科院分区：
文献类型：
--
作者：
BENNETT, MR
1.研究了刺激结肠带肌壁内抑制神经后自发活动细胞动作电位放电速率的增加和静止细胞动作电位放电的起始.在大多数以约1秒的间隔自发激发动作电位的细胞中，用单脉冲刺激壁内抑制神经产生抑制性连接电位（I.J.P.）随后是动作电位，其发生间隔小至0.5秒。增加的发射率持续了30秒。3.少数细胞不是自发活动的，就是仅以大于5秒的间隔激发动作电位。用单脉冲或重复脉冲刺激壁内抑制神经后，静止细胞产生I.J.P. S，随后产生单个动作电位或动作电位爆发.在一次I.J.P.后动作电位的放电率，并且这种增强的放电速率的持续时间随着I.J.P.期间超极化的平均幅度的增加而增加。由于I.J.P.的幅度随着神经的刺激频率的增加而增加，因此反弹兴奋随着抑制性神经的刺激频率的增加而增加。
1. A study has been made of the increase in the rate of action potential firing in spontaneously active cells and of the initiation of action potential firing in quiescent cells of the taenia coli after stimulation of the intramural inhibitory nerves.2. In the majority of cells which fired action potentials spontaneously at intervals of about 1 sec, stimulation of the intramural inhibitory nerves with single pulses gave an inhibitory junction potential (I.J.P.) which was followed by action potentials which occurred at intervals as small as 0·5 sec. The increased rate of firing lasted up to 30 sec.3. A small number of cells were either not spontaneously active or only fired action potentials at intervals greater than 5 sec. After stimulation of the intramural inhibitory nerves with either single or repetitive pulses, the quiescent cells gaveI.J.P.Swhich were followed by either a single action potential or a burst of action potentials.4. The rate of firing of action potentials after anI.J.P., and the duration of this enhanced rate of firing increased with an increase in the mean amplitude of the hyperpolarization during theI.J.P.As the amplitude of theI.J.P.increases with an increase in frequency of stimulation of the nerves, the rebound excitation increases with an increase in the frequency of stimulation of the inhibitory nerves.