Phase diagram of a 4-component lipid mixture: DSPC/DOPC/POPC/chol.

Phase diagram of a 4-component lipid mixture: DSPC/DOPC/POPC/chol.
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DOI:
10.1016/j.bbamem.2013.05.020
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发表时间:
2013-09
期刊:
Biochimica et biophysica acta
影响因子:
--
通讯作者:
Feigenson GW
Feigenson GW
中科院分区:
其他
文献类型:
--
作者:
Konyakhina TM;Wu J;Mastroianni JD;Heberle FA;Feigenson GW

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我们报告的第一个4-组分相图的脂质双层混合物,DSPC/DOPC/POPC/胆固醇(二硬脂酰磷脂酰胆碱/二油酰磷脂酰胆碱/1-棕榈酰,2-油酰磷脂酰胆碱/胆固醇)。具有宏观Ld + Lo相域的该相图清楚地表明,对于含有DOPC的3组分混合物确定的所有相边界平滑地过渡到含有POPC的3组分混合物的边界,所述3组分混合物具有Ld + Lo的纳米级相域。我们的研究从两个公布的三元相图,并显示如何将这些可以结合成一个四元相图的研究几百个样品的中间组合物。
We report the first 4-component phase diagram for the lipid bilayer mixture, DSPC/DOPC/POPC/chol (distearoylphosphatidylcholine/dioleoylphosphatidylcholine/1-palmitoyl, 2-oleoylphosphatidylcholine/cholesterol). This phase diagram, which has macroscopic Ld + Lo phase domains, clearly shows that all phase boundaries determined for the 3-component mixture containing DOPC transition smoothly into the boundaries for the 3-component mixture containing POPC, which has nanoscopic phase domains of Ld + Lo. Our studies start from two published ternary phase diagrams, and show how these can be combined into a quaternary phase diagram by study of a few hundred samples of intermediate compositions.
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影响因子: 3.4
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