Effect of Δ-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults
Effect of Δ-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults
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DOI：
10.1097/01.jcp.0000125688.05091.8f
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发表时间：
2004-06-01
影响因子：
2.9
通讯作者：
Robson, PJ
中科院分区：
文献类型：
--
作者：
Nicholson, AN;Turner, C;Robson, PJ
在8名健康志愿者（4名男性，4名女性; 21至34岁）中研究了大麻提取物对夜间睡眠，清晨表现，记忆和嗜睡的影响。本研究为双盲、安慰剂对照、4向交叉设计。4种治疗是安慰剂，15 mg Delta-9-四氢大麻酚（THC），5 mg THC与5 mg大麻二酚（CBD）的组合，以及15 mg THC与15 mg CBD的组合。将这些药物配制在50：50乙醇与丙二醇中，并在从10 PM开始的30分钟内使用奥罗莫替尼喷雾剂给药。在睡眠期间（晚上11点到早上7点）记录脑电图。从上午8：30（给药后10小时）开始测量表现、睡眠潜伏期以及嗜睡和情绪的主观评估。15 mg THC对夜间睡眠没有影响。伴随药物（5 mg THC和5 mg CBD至15 mg THC和15 mg CBD）的同时施用，第3阶段睡眠减少，并且随着更高剂量的组合，觉醒增加。第二天，使用15 mg THC，记忆受损，睡眠潜伏期缩短，受试者报告嗜睡增加和情绪变化。使用较低剂量的组合，数字回忆任务的反应时间更快，而使用较高剂量的组合，受试者报告嗜睡增加和情绪变化。15毫克THC似乎具有镇静作用，而15毫克CBD似乎具有警示作用，因为它增加了睡眠期间的清醒活动，并抵消了15毫克THC的残留镇静作用。
The effects of cannabis extracts on nocturnal sleep, early-morning performance, memory, and sleepiness were studied in 8 healthy volunteers (4 males, 4 females; 21 to 34 years). The study was double-blind and placebo-controlled with a 4-way crossover design. The 4 treatments were placebo, 15 mg Delta-9-tetrahydrocannabinol (THC), 5 mg THC combined with 5 mg cannabidiol (CBD), and 15 mg THC combined with 15 mg CBD. These were formulated in 50:50 ethanol to propylene glycol and administered using an oromucosal spray during a 30-minute period from 10 PM. The electroencephalogram was recorded during the sleep period (11 PM to 7 AM). Performance, sleep latency, and subjective assessments of sleepiness and mood were measured from 8:30 AM (10 hours after drug administration). There were no effects of 15 mg THC on nocturnal sleep. With the concomitant administration of the drugs (5 mg THC and 5 mg CBD to 15 mg THC and 15 mg CBD), there was a decrease in stage 3 sleep, and with the higher dose combination, wakefulness was increased. The next day, with 15 mg THC, memory was impaired, sleep latency was reduced, and the subjects reported increased sleepiness and changes in mood. With the lower dose combination, reaction time was faster on the digit recall task, and with the higher dose combination, subjects reported increased sleepiness and changes in mood. Fifteen milligrams THC would appear to be sedative, while 15 mg CBD appears to have alerting properties as it increased awake activity during sleep and counteracted the residual sedative activity of 15 mg THC.