Human-specific changes in two functional enhancers of FOXP2.
Human-specific changes in two functional enhancers of FOXP2.
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DOI：
10.14715/cmb/2022.68.11.3
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发表时间：
2022-11-30
期刊：
影响因子：
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通讯作者：
Garcia-Bellido, Paloma
中科院分区：
文献类型：
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作者：
Benitez-Burraco, Antonio;Torres-Ruiz, Raul;Garcia-Bellido, Paloma
FOXP2是一个参与语言发育和功能的基因。尼安德特人和人类共享相同的基因编码区，尽管前者被认为表现出不太复杂的语言能力。在本文中，我们报告了几个人类特异性的变化，在两个功能增强FOXP2。这些变体中的两个分别位于转录因子POLR2A和SMARCC1的结合位点内。有趣的是，SMARCC1参与大脑发育和维生素D代谢。我们推测，与灭绝的古人类相比，人类在这个位置的特定变化可能导致我们物种中FOXP2表达的不同调控模式，对我们的语言能力产生潜在影响。
FOXP2 is a gene involved in language development and function. Neanderthals and humans share the same coding region of the gene, although the formers are thought to have exhibited less sophisticated language abilities. In this paper, we report on several human-specific changes in two functional enhancers of FOXP2. Two of these variants are located within the binding sites for the transcription factors POLR2A and SMARCC1, respectively. Interestingly, SMARCC1 is involved in brain development and vitamin D metabolism. We hypothesize that the human specific change in this position might have resulted in a different regulation pattern of FOXP2 expression in our species compared to extinct hominins, with a potential impact on our language abilities.