Cigarette smoking in Parkinson's disease: Influence on disease progression
Cigarette smoking in Parkinson's disease: Influence on disease progression
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DOI：
10.1002/mds.20117
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发表时间：
2004-09-01
影响因子：
8.6
通讯作者：
Larsen, JP
中科院分区：
文献类型：
--
作者：
Alves, G;Kurz, M;Larsen, JP
先前的研究表明吸烟与帕金森病（PD）的患病率呈负相关，这表明吸烟可能会产生针对黑质神经元损伤的生物保护作用。 1993 年，我们检查了 239 名 PD 患者和两个对照组的吸烟频率。此外，我们对吸烟和不吸烟帕金森病患者的帕金森病进展和其他临床特征进行了为期 8 年的前瞻性跟踪。还检查了两个 PD 组的死亡率。我们发现对照组吸烟者的患病率比 PD 患者高 50%。相比之下，在随访期间，吸烟和不吸烟的帕金森病患者的帕金森病进展、认知障碍和情绪没有显着差异。两组的死亡率也相似。对疾病进展缺乏影响可能表明吸烟对已诊断为帕金森病的患者没有主要的神经保护作用。 (C) 2004 年运动障碍协会。
Previous studies have shown an inverse association between smoking and the prevalence of Parkinson's disease (PD), suggesting that smoking may induce a biological protection against nigral neuronal damage. In 1993, we examined the frequency of cigarette smokers among 239 patients with PD and two control groups. In addition, the progression of parkinsonism and other clinical features were followed prospectively in smoking and nonsmoking PD patients over an 8-year period. Mortality in the two PD groups was also examined. We found a 50% higher prevalence of smokers in the control groups than in patients with PD. In contrast, during the follow-up period, there were no significant differences in progression of parkinsonism, cognitive impairment, and mood in smoking and nonsmoking patients with PD. Mortality was also similar in the two groups. The lack of influence on disease progression may indicate that cigarette smoking does not have a major neuroprotective effect in patients with already diagnosed PD. (C) 2004 Movement Disorder Society.