JBIR-23 and-24, Novel Anticancer Agents from Streptomyces sp AK-AB27
JBIR-23 and-24, Novel Anticancer Agents from Streptomyces sp AK-AB27
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DOI：
10.1021/ol802611w
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发表时间：
2009-01-15
期刊：
影响因子：
5.2
通讯作者：
Shin-ya, Kazuo
中科院分区：
文献类型：
--
作者：
Motohashi, Keiichiro;Hwang, Ji-Hwan;Shin-ya, Kazuo
对链霉菌AK-AB 27产生的抗恶性胸膜间皮瘤（MPM）细胞的活性化合物进行筛选，结果分离出两种具有十二氢二苯并[B，d]呋喃骨架的化合物，命名为JBIR-23（1）和-24（2）。它们的结构是建立在广泛的NMR和MS分析的基础上。化合物1和2对几种MPM细胞系表现出细胞毒性作用。
The screening for active compounds against malignant pleural mesothelioma (MPM) cells produced by Streptomyces sp. AK-AB27 resulted in the isolation of two compounds with a dodecahydrodibenzo[b,d]furan skeleton named JBIR-23 (1) and -24 (2). Their structures were established on the basis of extensive NMR and MS analyses. Compounds 1 and 2 exhibited cytotoxic effects against several MPM cell lines.