Glycans and glycan-binding proteins in immune regulation: A concise introduction to glycobiology for the allergist.
Glycans and glycan-binding proteins in immune regulation: A concise introduction to glycobiology for the allergist.
复制标题
免疫调节中的聚糖和聚糖结合蛋白：过敏症患者的糖生物学简明介绍。
DOI：
10.1016/j.jaci.2014.10.057
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发表时间：
2015-03
影响因子：
14.2
通讯作者：
Schnaar, Ronald L.
中科院分区：
文献类型：
--
作者：
Schnaar, Ronald L.
细胞具有丰富的聚糖表面涂层，作为糖蛋白和糖脂携带在其质膜的外层，并构成细胞与其环境之间的主要分子界面。每个细胞的糖组是其不同聚糖结构的总和，包含独特的细胞特征，该特征由负责聚糖生物合成的酶的表达水平定义。该特征可以通过互补聚糖结合蛋白来读取，将聚糖识别转化为功能。这一点在免疫系统中最为明显，其中聚糖和聚糖结合蛋白是病原体识别和炎症反应控制不可或缺的一部分。糖生物学——对聚糖结构及其功能的研究——越来越多地提供对免疫调节机制的见解，从而为治疗干预提供机会。为了促进对这一快速扩展的研究领域的更广泛认识，本文简要研究了人类糖组（将聚糖识别转化为功能的聚糖结合蛋白）的构成，并提供了负责免疫系统调节的聚糖识别事件的示例。
Cells are endowed with a rich surface coat of glycans carried as glycoproteins and glycolipids on the outer leaflet of their plasma membranes and constituting a major molecular interface between cells and their environment. Each cell’s glycome, the sum of its diverse glycan structures, comprises a distinct cellular signature that is defined by the expression levels of the enzymes responsible for glycan biosynthesis. This signature can be read by complementary glycan binding proteins that translate glycan recognition into function. Nowhere is this more evident than in the immune system, where glycans and glycan binding proteins are integral to pathogen recognition and the control of inflammatory responses. Glycobiology – the study of glycan structures and their functions – is increasingly providing insights into immune regulatory mechanisms and thereby providing opportunities for therapeutic intervention. To promote wider appreciation of this rapidly expanding area of research, this review briefly examines the makeup of the human glycome, the glycan binding proteins that translate glycan recognition into function, and provides examples of glycan recognition events that are responsible for immune system regulation.
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DOI：
10.4049/jimmunol.1200776
发表时间：
2012-09-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Klaas M;Oetke C;Lewis LE;Erwig LP;Heikema AP;Easton A;Willison HJ;Crocker PR
通讯作者：
Crocker PR
影响因子：
4.8
作者：
Hellbusch, Christina C.;Sperandio, Markus;Korner, Christian
通讯作者：
Korner, Christian
影响因子：
4.8
作者：
Grigorian, Ani;Lee, Sung-Uk;Demetriou, Michael
通讯作者：
Demetriou, Michael
DOI：
10.1111/j.1749-6632.2009.05131.x
发表时间：
2010-01-01
期刊：
YEAR IN IMMUNOLOGY 2
影响因子：
--
作者：
Liu, Fu-Tong;Rabinovich, Gabriel A.
通讯作者：
Rabinovich, Gabriel A.
影响因子：
3.3
作者：
Li, Carey F.;Zhou, Raymond W.;Demetriou, Michael
通讯作者：
Demetriou, Michael