Auditory sensory memory and the aging brain: A mismatch negativity study
Auditory sensory memory and the aging brain: A mismatch negativity study
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DOI：
10.1016/j.neurobiolaging.2005.03.012
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发表时间：
2006-05-01
影响因子：
4.2
通讯作者：
Michie, PT
中科院分区：
文献类型：
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作者：
Cooper, RJ;Todd, J;Michie, PT
听觉事件相关电位的失匹配负波（MMN）成分过去曾被用于研究听觉感觉记忆（ASM）中信息准确性和保留的组间差异。MMN是由与重复的“标准”音调不同的不常见的“偏差”音调引起的。在本研究中，异常的类型和音调之间的时间间隔（刺激发作的时间间隔：SOA）在正常老化的研究中被操纵。在短（450 ms）和长（3 s）SOA下测量了老年组（平均年龄= 69）和年轻组（平均年龄= 21）对持续时间和频率偏差音的MMN响应。在SOA和偏离条件下，相对于年轻组，在老年组中观察到较小且较晚的MMN（在Fz记录）。结果是一致的，在编码的声音属性在ASM的一个电子相关的赤字。然而，在乳突MMN逆转的分析提供了一些支持的建议，老年人有一个额外的赤字有关的保留信息在ASM。(c)2005年爱思唯尔公司All rights reserved.
The mismatch negativity (MMN) component of the auditory event-related potential has been used in the past to study between group differences in the accuracy and retention of information in auditory sensory memory (ASM). The MMN is elicited by infrequent 'deviant' tones that differ from a repeating 'standard' tone. In the present study, the type of deviant and the time interval between tones (stimulus-onset asynchrony: SOA) were manipulated in a study of normal aging. MMN responses of an elderly (mean age = 69) and a young group (mean age = 21) to both a duration and a frequency deviant tone were measured at a short (450 ms) and long (3 s) SOA. A smaller and later MMN (recorded at Fz) was observed in the elderly relative to the young group across SOA and Deviant conditions. The results are consistent with an a-e-related deficit in the encoding of sound properties in ASM. However, analysis of the MMN reversal at the mastoids provides some support for the proposal that the elderly have an additional deficit related to the retention of information in ASM. (c) 2005 Elsevier Inc. All rights reserved.