High-contrast grating resonators for label-free detection of disease biomarkers.
High-contrast grating resonators for label-free detection of disease biomarkers.
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DOI：
10.1038/srep27482
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发表时间：
2016-06-06
影响因子：
4.6
通讯作者：
Chang-Hasnain C
中科院分区：
文献类型：
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作者：
Sun T;Kan S;Marriott G;Chang-Hasnain C
描述了一种无标记的光学生物传感器，其采用基于硅的高对比度光栅（HCG）谐振器，其光谱线宽为~500 μ m，其对配体诱导的表面性质的变化敏感。该装置用于生成表面附着抗体及其相应抗原的热力学和动力学数据。该设备可以在4分钟内检测血清心肌肌钙蛋白I（心脏病的生物标志物）至100 pg/ml，这更快，并且与当前的cTnI酶联免疫测定法一样灵敏。
A label-free optical biosensor is described that employs a silicon-based high-contrast grating (HCG) resonator with a spectral linewidth of ~500 pm that is sensitive to ligand-induced changes in surface properties. The device is used to generate thermodynamic and kinetic data on surface-attached antibodies with their respective antigens. The device can detect serum cardiac troponin I, a biomarker of cardiac disease to 100 pg/ml within 4 mins, which is faster, and as sensitive as current enzyme-linked immuno-assays for cTnI.