STORAGE OF 7+/-2 SHORT-TERM MEMORIES IN OSCILLATORY SUBCYCLES
STORAGE OF 7+/-2 SHORT-TERM MEMORIES IN OSCILLATORY SUBCYCLES
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DOI：
10.1126/science.7878473
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发表时间：
1995-03-10
期刊：
影响因子：
56.9
通讯作者：
IDIART, MAP
中科院分区：
文献类型：
--
作者：
LISMAN, JE;IDIART, MAP
心理物理测量表明，人类受试者可以存储大约7个短期记忆。生理学研究表明，短期记忆是通过神经元活动模式储存的。研究表明，与多个记忆相关的活动模式可以存储在一个单一的神经网络中，该神经网络显示出与大脑记录的相似的嵌套振荡。每个存储器存储在一个低频振荡的不同高频（“40赫兹”）子周期中。记忆模式在每次低频（5到12赫兹）振荡中重复，这种重复依赖于膜兴奋性的活动依赖性变化，而不是混响回路。这项工作表明，大脑振荡是一种控制短期记忆序列处理的定时机制。
Psychophysical measurements indicate that human subjects can store approximately seven short-term memories. Physiological studies suggest that short-term memories are stored by patterns of neuronal activity. Here it is shown that activity patterns associated with multiple memories can be stored in a single neural network that exhibits nested oscillations similar to those recorded from the brain. Each memory is stored in a different high-frequency (''40 hertz'') subcycle of a low-frequency oscillation. Memory patterns repeat on each low-frequency (5 to 12 hertz) oscillation, a repetition that relies on activity-dependent changes in membrane excitability rather than reverberatory circuits. This work suggests that brain oscillations are a timing mechanism for controlling the serial processing of short-term memories.