The new bronchopulmonary dysplasia.
The new bronchopulmonary dysplasia.
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DOI：
10.1097/mop.0b013e3283423e6b
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发表时间：
2011-04
影响因子：
3.6
通讯作者：
Jobe AH
中科院分区：
文献类型：
--
作者：
Jobe AH
BPD仍然是早产最常见的严重并发症。最近的一些动物模型和临床研究提供了关于病理生理学和治疗的新信息。BPD的流行病学继续证明出生体重或胎龄是BPD的最佳预测因素。BPD与绒毛膜炎的相关性被胎儿暴露于炎症的复杂性所掩盖。早产儿过度使用氧气可增加BPD的风险，但低饱和度目标可能会增加死亡。许多最近的试验表明，许多早产儿在分娩后最初可以通过CPAP稳定下来，然后选择性地使用表面活性剂治疗RDS。BPD婴儿的肺部发育在整个童年期的特征仍然很差。最近的经验表明，结合微创护理策略，避免过度供氧和通气，减少产后感染，优化营养可能会降低BPD的发病率和严重程度。
BPD remains the most common severe complication of preterm birth. A number of recent animal models and clinical studies provide new information about pathophysiology and treatment. The epidemiology of BPD continues to demonstrate that birth weight or gestational age are most predictive of BPD. Correlations of BPD with chorioamnionitis are clouded by the complexity of the fetal exposures to inflammation. Excessive oxygen use in preterm infants can increase the risk of BPD, but low saturation targets may increase death. Numerous recent trials demonstrate that many preterm infants can be initially stabilized after delivery with CPAP and then be selectively treated with surfactant for RDS. The growth of the lungs of the infant with BPD through childhood remains poorly characterized. Recent experiences in neonatology suggest that combining less invasive care strategies that avoid excessive oxygen and ventilation, decrease postnatal infections, and optimize nutrition may decrease the incidence and severity of BPD.