The human β-globin gene contains a downstream developmental specific enhancer

The human β-globin gene contains a downstream developmental specific enhancer
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人类β-珠蛋白基因含有下游发育特异性增强子

DOI：
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发表时间：
1987
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影响因子：
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通讯作者：
F. Grosveld
F. Grosveld
中科院分区：
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文献类型：
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作者：
G. Kollias;J. Hurst;E. Deboer;F. Grosveld

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人β-珠蛋白基因是一个多基因家族的一部分， 特别是在成人红细胞组织中（综述，1）。当人类 β-珠蛋白被引入受精的小鼠卵中，它首先在受精卵中被激活。 胎儿肝脏和成人红细胞组织中表达的残留物（2，3，4）。它 因此模仿其鼠对应物的表达模式。它有 先前在组织培养（5）和转基因小鼠（4）中显示， 0-珠蛋白启动子下游的序列参与了这一过程。 调控我们现在表明，这些序列中至少有一部分位于 位于polyA添加位点下游0.5-1.2kb处，并构成一个 转录增强子元件是红细胞和发育特异性的。
textabstractThe human P-globin gene is part of a multigene family and is expressed specifically in adult human erythroid tissue (for review, 1). When the human P-globin is introduced into fertilized mouse eggs, it is first activated in foetal liver and remains expressed in adult erythroid tissues (2,3,4). It therefore mimicks the pattern of expression of its murine counterpart. It has previously been shown in tissue culture (5) and transgenic mice (4) that sequences downstream from the 0-globin promoter are involved in this regulation. We now show that at least part of these sequences are located 0.5-1.2kb downstream from the polyA addition site and constitute a transcriptional enhancer element that is erythroid and developmental specific.