Oxygen Saturation Imaging Using LED-Based Photoacoustic System.
Oxygen Saturation Imaging Using LED-Based Photoacoustic System.
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DOI：
10.3390/s21010283
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发表时间：
2021-01-04
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影响因子：
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通讯作者：
Francis KJ
中科院分区：
文献类型：
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作者：
Bulsink R;Kuniyil Ajith Singh M;Xavierselvan M;Mallidi S;Steenbergen W;Francis KJ
氧饱和度成像在几个临床前和临床应用中具有潜力。在这种情况下，基于双波长LED阵列的光声氧饱和度成像可以是负担得起的解决方案。对于这项技术的翻译，需要提高其准确性，并根据地面实况方法对其进行验证。我们提出了一种注量补偿的氧饱和度成像方法，利用超声图像的结构信息，和先验知识的光学性质的组织与蒙特-卡罗为基础的光传播模型的双波长LED阵列配置。然后，我们验证所提出的方法与血氧计测量组织模仿幻影。此外，我们证明在小动物和人类受试者的体内成像。我们的结论是，建议的氧饱和度成像可用于在6-8 mm的深度在临床前和临床应用中的图像组织。
Oxygen saturation imaging has potential in several preclinical and clinical applications. Dual-wavelength LED array-based photoacoustic oxygen saturation imaging can be an affordable solution in this case. For the translation of this technology, there is a need to improve its accuracy and validate it against ground truth methods. We propose a fluence compensated oxygen saturation imaging method, utilizing structural information from the ultrasound image, and prior knowledge of the optical properties of the tissue with a Monte-Carlo based light propagation model for the dual-wavelength LED array configuration. We then validate the proposed method with oximeter measurements in tissue-mimicking phantoms. Further, we demonstrate in vivo imaging on small animal and a human subject. We conclude that the proposed oxygen saturation imaging can be used to image tissue at a depth of 6–8 mm in both preclinical and clinical applications.