Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair.
Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair.
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DOI：
10.1016/j.addr.2015.03.013
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发表时间：
2015-11-01
影响因子：
16.1
通讯作者：
García AJ
中科院分区：
文献类型：
--
作者：
Agarwal R;García AJ
骨组织具有非凡的自我再生和愈合能力。然而，大面积骨缺损和复杂骨折仍然是医学界面临的重大挑战。目前的治疗中心是金属植入物的结构和机械支持和自体或异体移植物，以取代长骨缺损。金属植入物与几种并发症有关，如植入物松动和感染。骨移植物遭受供体部位发病率、降低的生物活性和病原体传播的风险。外科植入物可以被修改以提供重要的生物学信号、生长因子和细胞，以改善骨整合和骨缺损的修复。在这里，我们审查的策略和技术，工程金属表面，以促进与宿主组织的骨整合。我们还讨论了通过整合素信号传导和生长因子和细胞因子递送来修饰骨缺损修复的细胞粘附和骨生长的植入物的策略。
Bone tissue has a remarkable ability to regenerate and heal itself. However, large bone defects and complex fractures still present a significant challenge to the medical community. Current treatments center on metal implants for structural and mechanical support and auto- or allo-grafts to substitute long bone defects. Metal implants are associated with several complications such as implant loosening and infections. Bone grafts suffer from donor site morbidity, reduced bioactivity, and risk of pathogen transmission. Surgical implants can be modified to provide vital biological cues, growth factors and cells in order to improve osseointegration and repair of bone defects. Here we review strategies and technologies to engineer metal surfaces to promote osseointegration with the host tissue. We also discuss strategies for modifying implants for cell adhesion and bone growth via integrin signaling and growth factor and cytokine delivery for bone defect repair.