Familial aggregation for conduct disorder symptomatology: the role of genes, marital discord and family adaptability
Familial aggregation for conduct disorder symptomatology: the role of genes, marital discord and family adaptability
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DOI：
10.1017/s0033291799002408
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发表时间：
2000-07-01
影响因子：
6.9
通讯作者：
Eaves, LJ
中科院分区：
文献类型：
--
作者：
Meyer, JM;Rutter, M;Eaves, LJ
背景有大量的证据表明，家庭不和/适应不良和反社会行为的儿童之间的统计关联，但问题是：主要的精神病理风险的程度是遗传或环境介导的。双胞胎对（N = 1350），年龄在8至16岁，在一般人群为基础的弗吉尼亚州双胞胎青少年行为发展研究进行了评估，使用儿童和青少年精神病学评估访谈分别管理的双胞胎和父母双方。父母一生的精神疾病的结构化访谈也管理的母亲和父亲。母亲报告Olsson的家庭适应性和凝聚力问卷和二元调整量表被用作家庭环境的指数。采用扩展双家系设计的路径分析模型对品行障碍遗传学的亲子相似性假设进行了检验。家庭不和和适应不良，其相关系数为0.63，与品行障碍的风险增加约2倍相关。当父母品行障碍被纳入模型时，环境对家庭适应不良的中介作用仍然存在，但对家庭不和谐的中介作用丧失。它的结论是，有真正的环境调解家庭适应不良，作为一个共享的效果，占3.5%的表型方差。这一遗传研究策略的基本假设是明确的，连同其优点和局限性。
Background. There is extensive evidence of statistical associations between family discord/maladaptation and antisocial behaviour in the children, but questions re:main on the extent to which the psychopathological risks are genetically or environmentally mediated.Methods. Twin pairs (N = 1350), aged 8 to 16 years, in the general population-based Virginia Twin Study of Adolescent Behavioral Development were assessed using the Child and Adolescent Psychiatric Assessment interview administered separately to both twins and both parents. Structured interviews for parental lifetime psychiatric disorders were also administered to the mothers and fathers. Maternal reports on Olsson's Family Adaptability and Cohesiveness questionnaire and the Dyadic Adjustment Scale were used as indices of the family environment. A path analytical model based on an extended twin-family design was used to test hypotheses about parent-offspring similarity for conduct disorder symptomatology.Results. Family discord and maladaptation, which intercorrelated at 0.63, were associated with a roughly two-fold increase in risk for conduct disorder symptomatology. When parental conduct disorder was included in the model the environmental mediation effect for family maladaptation remained, but that for family discord was lost.Conclusion. It is concluded that there is true environmental mediation from family maladaptation, operating as a shared effect, which accounts for 3.5 % of the phenotypic variance. The assumptions underlying this genetic research strategy are made explicit, together with its strengths and limitations.