New insight into the mechanism of hip prosthesis loosening: effect of titanium debris size on osteoblast function
New insight into the mechanism of hip prosthesis loosening: effect of titanium debris size on osteoblast function
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DOI：
10.1016/s0736-0266(03)00167-0
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发表时间：
2004-03-01
影响因子：
2.8
通讯作者：
Sung, KLP
中科院分区：
文献类型：
--
作者：
O'Connor, DT;Choi, MG;Sung, KLP
类风湿性关节炎和骨关节炎的发病率正在上升，由于我们不断扩大的老年人口。全关节置换术是这些和其他退行性髋关节疾病最成功、最普遍的治疗方式。尽管市场上有各种各样的假体装置，但髋关节假体有一个共同的问题，即骨组织和骨-植入物界面完整性逐渐然后加速丧失，随后是植入物不稳定和松动。植入物失效主要是由于器械不可避免的磨损和磨损碎屑的产生。为了提供改进假体磨损特性的信息，我们研究了尺寸分离的钛颗粒对骨形成细胞群的影响。我们明确地证明，颗粒大小是体外成骨细胞的功能，增殖和生存能力的关键因素。此外，我们已经阐明了成骨细胞内吞噬颗粒的时间依赖性分布，表明受影响细胞的核周区域中颗粒的积累。该报告发现，颗粒大小是暴露于模拟磨损碎屑的成骨细胞的骨形成相关功能变化的关键因素，并且1.5-4 μ m钛颗粒对体外成骨细胞增殖和活力的影响最大。在开发上级植入物技术时，假体磨损产生的钛颗粒尺寸可能是一个重要的考虑因素。(C)2003骨科研究学会。由爱思唯尔有限公司出版。保留所有权利。
The incidence of rheumatoid arthritis and osteoarthritis is on the rise due to our expanding elderly population. Total joint arthroplasty is the most successful, prevalent treatment modality for these and other degenerative hip conditions. Despite the wide array of prosthetic devices commercially available, hip prostheses share a common problem with a gradual and then accelerating loss of bone tissue and bone-implant interface integrity, followed by implant instability and loosening. Implant failure is largely the result of inevitable wear of the device and generation of wear debris. To provide information for the development of improved prosthetic wear characteristics, we examined the effects of size-separated titanium particles on bone forming cell populations. We demonstrate unequivocally that particle size is a critical factor in the function, proliferation, and viability of bone-forming osteoblasts in vitro. In addition, we have elucidated the time-dependent distribution of the phagocytosed particles within the osteoblast, indicating an accumulation of particles in the perinuclear area of the affected cells. The report finds that particle size is a critical factor in changes in the bone formation-related functions of osteoblasts exposed to simulate wear debris, and that 1.5-4 mum titanium particles have the greatest effect on osteoblast proliferation and viability in vitro. The size of titanium particles generated through wear of a prosthetic device may be an important consideration in the development of superior implant technology. (C) 2003 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved.