Numerical investigation of physiologically realistic pulsatile flow through arterial stenosis
Numerical investigation of physiologically realistic pulsatile flow through arterial stenosis
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DOI：
10.1016/s0021-9290(01)00100-2
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发表时间：
2001-10-01
影响因子：
2.4
通讯作者：
Hoskins, P
中科院分区：
文献类型：
--
作者：
Long, Q;Xu, XY;Hoskins, P
对直管狭窄模型中的脉动血流进行了数值模拟，以研究狭窄后的流动现象。在这项研究中，三个轴对称和三个不对称的狭窄模型，面积减少25%，50%和75%。测量的人颈总动脉血流波形被用作上游流动条件，其具有平均300的波罗蜜数。所有的计算都以高的空间和时间分辨率进行。流量功能，如速度剖面，流动分离区（FSZ），和壁面剪应力（WSS）分布在狭窄后区域的所有模型。结果表明，狭窄后区FSZ的形成和发展是非常复杂的，特别是在流动减速阶段。在轴对称狭窄中，狭窄后血流对狭窄程度的变化比非对称模型更敏感。对于严重狭窄，非对称模型的狭窄影响长度比轴对称模型短。在一些模型中，在不同的下游位置观察到WSS振荡（正值和负值之间）。振荡的幅度强烈地依赖于轴向位置和狭窄程度。(C)2001爱思唯尔科技有限公司版权所有。
Numerical simulations of pulsatile blood flow in straight tube stenosis models were performed to investigate the poststenotic flow phenomena. In this study, three axisymmetrical and three asymmetrical stenosis models with area reduction of 25%, 50%, and 75% were constructed. A measured human common carotid artery blood flow waveform was used as the upstream flow condition which has a mean Reynold's number of 300. All calculations were performed with high spatial and temporal resolutions. Flow features such as velocity profiles, flow separation zone (FSZ), and wall shear stress (WSS) distributions in the poststenotic region for all models are presented. The results have demonstrated that the formation and development of FSZs in the poststenotic region are very complex, especially in the flow deceleration phase. In axisymmetric stenoses the poststenotic flow is more sensitive to changes in the degree of stenosis than in asymmetric models. For severe stenoses, the stenosis influence length is shorter in asymmetrical models than in axisymmetrical cases. WSS oscillations (between positive and negative values) have been observed at various downstream locations in some models. The amplitude of the oscillation depends strongly on the axial location and the degree of stenosis. (C) 2001 Elsevier Science Ltd. All rights reserved.