EFFECT OF ALPHA-MELANOCYTE-STIMULATING HORMONE ON BASAL AND STIMULATED RELEASE OF PROLACTIN - EVIDENCE FOR DOPAMINERGIC MEDIATION
EFFECT OF ALPHA-MELANOCYTE-STIMULATING HORMONE ON BASAL AND STIMULATED RELEASE OF PROLACTIN - EVIDENCE FOR DOPAMINERGIC MEDIATION
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DOI：
10.1159/000123341
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发表时间：
1982-01-01
影响因子：
4.1
通讯作者：
MCCANN, SM
中科院分区：
文献类型：
--
作者：
KHORRAM, O;MIZUNUMA, H;MCCANN, SM
.alpha的效果。-MSH对泌乳素基础释放和刺激释放的影响。脑室内注射2 .mu。G （）在去卵巢大鼠（OVX）中，-MSH在10分钟内使血浆催乳素水平降低50%，而100 ng的。-MSH或生理盐水无效。2 .mu。G （）如果初始催乳素浓度升高，msh （i.v.t）产生更显著和持续的催乳素水平下降。这一剂。-MSH也能有效降低OVX大鼠的血浆水平，在72小时前注射50 .mu。g的苯甲酸雌二醇（s.c.），尽管这种抑制的相对程度低于未启动的OVX动物。静脉注射多巴胺受体阻滞剂螺哌啶醇（0.1 mg/kg）。.alpha。-MSH阻断了。α的抑制作用。-剂量为0.5至5 μ mu的msh。g对雄性或OVX雌性大鼠的半垂体和雌性大鼠分散的垂体细胞的泌乳素释放没有影响。-MSH可能通过下丘脑多巴胺能系统调节催乳素的释放，这种调节在应激时可能更重要。
The effects of .alpha.-MSH on basal and stimulated release of prolactin were studied. Intraventricular (i.v.t.) injection of 2 .mu.g of .alpha.-MSH in ovariectomized (OVX) rats produced a 50% depression of plasma prolactin levels within 10 min, whereas 100 ng of .alpha.-MSH or saline had no effect. 2 .mu.g of .alpha.-MSH (i.v.t.) produced a more dramatic and sustained depression of prolactin levels if initial prolactin concentrations were elevated. This dose of .alpha.-MSH was also effective in lowering plasma levels in OVX rats, primed 72 h earlier with 50 .mu.g of estradiol benzoate (s.c.), although this depression was of lower relative magnitude than in the unprimed OVX animals. The i.v. injection of a dopamine receptor blocker, spiroperidol (0.1 mg/kg), prior to (i.v.t.) .alpha.-MSH blocked the inhibitory effect of .alpha.-MSH in doses ranging from 0.5 to 5 .mu.g did not alter prolactin release from hemipituitaries of male or OVX female rats and from dispersed pituitary cels from females rats. .alpha.-MSH can modulate prolactin release possibly via the hypothalamic dopaminergic system, and this modulation may be of greater significance during stress.