Plasma CTRP-3 concentrations in Chinese patients with obesity and type II diabetes negatively correlate with insulin resistance
Plasma CTRP-3 concentrations in Chinese patients with obesity and type II diabetes negatively correlate with insulin resistance
复制标题
中国肥胖和II型糖尿病患者血浆CTRP-3浓度与胰岛素抵抗呈负相关
DOI：
10.1016/j.jacl.2015.03.006
复制
发表时间：
2015-06-01
影响因子：
4.4
通讯作者：
Deng, Huacong
中科院分区：
文献类型：
--
作者：
Qu, Hua;Deng, Min;Deng, Huacong
背景技术背景：分析中国人群中血浆C1 q/TNF相关蛋白-3（CTRP-3）浓度与肥胖和2型糖尿病的关系。分析了174名中国肥胖受试者（n = 43）、II型糖尿病受试者（n = 41）、肥胖合并II型糖尿病受试者（n = 45）和健康受试者（n = 45）的血浆CTRP-3浓度，结果：肥胖和II型糖尿病患者的血浆CTRP-3浓度显著低于健康受试者（P <0.01）。肥胖的II型糖尿病患者的CTRP-3浓度最低。相关性分析显示，CTRP-3与体重指数、腰围、空腹血糖、2 h血糖、血红蛋白A1 c、甘油三酯、空腹胰岛素、胰岛素抵抗模型评估、白细胞介素6水平呈显著负相关，与高密度脂蛋白胆固醇水平呈正相关（均P <0.01）。多元线性回归分析显示，血红蛋白A1 c（β =-0.232，P = 0.023）、甘油三酯（β =-0.147，P = 0.040）和胰岛素抵抗的稳态模型评估（β =-0.172，P = 0.031）与循环CTRP-3独立相关。多因素Logistic回归分析显示，血浆CTRP-3浓度与肥胖显着相关，即使调整后的葡萄糖代谢factors.CONCLUSIONS：中国肥胖和II型糖尿病患者的血浆CTRP-3浓度显着低于健康受试者，血浆CTRP-3与糖和脂代谢，慢性炎症，胰岛素抵抗密切相关。(C)2015年全国脂质协会。All rights reserved.
BACKGROUND: To analyze the association between the plasma C1q/TNF-related protein-3 (CTRP-3) concentrations, obesity, and type II diabetes in the Chinese population.METHODS: The plasma CTRP-3 concentrations were analyzed in 174 Chinese subjects with obesity (n = 43), type II diabetes (n = 41), obesity combined with type II diabetes (n = 45), and healthy subjects (n = 45), as were various clinical parameters of obesity-related metabolic disorders and adipokines.RESULTS: The plasma CTRP-3 concentrations were significantly lower in patients with obesity and type II diabetes than in healthy subjects (P < .01). Obese type II diabetic patients had the lowest CTRP-3 concentrations. Correlation analysis revealed that the plasma CTRP-3 concentrations were significantly negatively correlated with body mass index, waist circumferences, fasting plasma glucose, 2 h plasma glucose, hemoglobin A1c, triglyceride, fasting insulin, homeostasis model assessment for insulin resistance, and interleukin 6 levels and were positively correlated with high-density lipoprotein cholesterol level (all P < .01). Multiple linear regression analysis showed that hemoglobin A1c (beta = -0.232, P = .023), triglyceride (beta = -0.147, P = .040), and homeostasis model assessment for insulin resistance (beta = -0.172, P = .031) were independently correlated with circulating CTRP-3. Multivariate logistic regression analysis revealed that plasma CTRP-3 concentrations were significantly correlated with obesity, even after adjusting for glucose metabolic factors.CONCLUSIONS: Chinese patients with obesity and type II diabetes have significantly lower plasma CTRP-3 concentrations than healthy subjects do, and plasma CTRP-3 is strongly associated with glucose and lipid metabolism, chronic inflammation, and insulin resistance. (C) 2015 National Lipid Association. All rights reserved.