Relationship between vertebral artery hypoplasia and posterior circulation stroke in Chinese patients
Relationship between vertebral artery hypoplasia and posterior circulation stroke in Chinese patients
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中国患者椎动脉发育不全与后循环脑卒中的关系
DOI：
10.1007/s00234-012-1112-y
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发表时间：
2013-02-01
期刊：
影响因子：
2.8
通讯作者：
Liu, Jian-Ren
中科院分区：
文献类型：
--
作者：
Hu, Xiao-Yue;Li, Zheng-Xi;Liu, Jian-Ren
椎动脉发育不全（VAH）在约10%的正常人中被发现，它不产生症状，但可能与脑后循环缺血性（PCI）卒中的风险增加有关。本研究的目的是确定VAH在中国脑梗死患者的患病率，并探讨VAH是否是PCI stroke.MethodsThe 841例中国脑卒中患者的病历进行了回顾性分析。所有患者均接受颈部对比增强磁共振血管造影（CE-MRA）或颈部计算机断层扫描血管造影（CTA）。VAH没有标准定义;我们将其定义为直径<2 mm的椎动脉，并且CE-MRA或CTA显示整个动脉纤细或缺失。单因素和多因素Logistic回归分析，以确定显着的独立危险因素PCI stroke.ResultsThere有230例（27.3%）被诊断为PCI卒中和91例被诊断为VAH（10.8%）。多因素Logistic回归分析显示，VAH，男性，和狭窄的后循环是独立的危险因素PCI stroke.ConclusionsOur结果表明，VAH并不罕见，在中国患者中风，它的存在增加了PCI中风的风险。
IntroductionVertebral artery hypoplasia (VAH), which has been found in about 10 % of normal individuals, does not produce symptoms but may be associated with an increased risk of cerebral posterior circulation ischemic (PCI) stroke. The aims of this study were to determine the prevalence of VAH in Chinese patients with cerebral infarction and investigate whether VAH is an independent risk factor for PCI stroke.MethodsThe medical records of 841 Chinese stroke patients were reviewed retrospectively. All patients underwent either cervical contrast-enhanced magnetic resonance angiography (CE-MRA) or cervical computed tomography angiography (CTA). There is no standard definition of VAH; we defined it as a vertebral artery <2 mm in diameter and the whole artery was slim or absent on CE-MRA or CTA. Univariate and multivariate logistic regression analyses were performed to identify significant independent risk factors for PCI stroke.ResultsThere were 230 patients (27.3 %) diagnosed with PCI stroke and 91 patients diagnosed with VAH (10.8 %). Multivariate logistic regression analysis showed that VAH, male gender, and stenosis of the posterior circulation were independent risk factors for PCI stroke.ConclusionsOur results show that VAH is not rare in Chinese patients with stroke and that its presence increases the risk of PCI stroke.