AGE-RELATED AND SEX-RELATED CHANGES IN ILIAC CORTICAL BONE MASS AND REMODELING
AGE-RELATED AND SEX-RELATED CHANGES IN ILIAC CORTICAL BONE MASS AND REMODELING
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DOI：
10.1016/8756-3282(93)90092-o
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发表时间：
1993-07-01
期刊：
影响因子：
4.1
通讯作者：
MELSEN, F
中科院分区：
文献类型：
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作者：
BROCKSTEDT, H;KASSEM, M;MELSEN, F
髂骨嵴骨活检标本来自64名正常人（41名女性和23名男性），年龄19-90岁（平均48.2岁）。34例在活检前用四环素进行双标记。在所有活检中测量以下变量：活检芯宽度（C.Wi）、绝对（A.Ct.Wi）和分数（F.Ct.Wi）皮质宽度、绝对（A.Cn.Wi）和分数（F.Cn.Wi）松质骨宽度、皮质孔隙率（Ct.Po）、骨单位直径（On.Dm）、哈佛管直径（Ha.Ca.Dm）和壁厚度（W.Th）。在四环素标记的活检组织中，重建了典型的皮质骨重建周期，并估计了激活频率。女性由于骨髓扩张，F、Ct、Wi随增龄而降低（p < 0.02）（p < 0.05）。此外，由于W.Th减少（p <0.01）和H.Ca.Dm增加（p <0.001），Ct.Po增加（p < 0.001）。在男性中，随着年龄的增长，皮质骨负平衡完全是由Ct.Po增加引起的（p < 0.001），部分原因是H.Ca.Dm增加（p < 0.01）。On.Dm随着年龄的增长而增加（p < 0.01），但令人惊讶的是，没有观察到W.Th的下降。重建的重塑周期并没有显示出任何显着差异，年轻女性和男性。然而，激活频率从绝经前的每年0.5次上升到绝经后妇女的每年1.0次（p < 0.001），导致高转换状态，重塑空间增加，从而在绝经后立即增加皮质骨的孔隙度。目前的研究表明，与年轻人相比，老年人的皮质骨质量减少，这可能是由年龄相关的重塑失衡解释的。由于绝经后骨转换加速，绝经后妇女的骨密度进一步降低。
Iliac crest bone biopsies were obtained from 64 normal individuals (41 women and 23 men) aged 19-90 (mean 48.2) years. Thirty-four were double-labeled with tetracycline before biopsy. The following variables were measured in all biopsies: biopsy core width (C.Wi), absolute (A.Ct.Wi) and fractional (F.Ct.Wi) cortical width, absolute (A.Cn.Wi) and fractional (F.Cn.Wi) cancellous width, cortical porosity (Ct.Po), osteon diameter (On.Dm), Haversian canal diameter (Ha.Ca.Dm), and wall thickness (W.Th). In the tetracycline-labeled biopsies the typical cortical remodeling cycle was reconstructed and the activation frequency was estimated.A negative cortical bone balance with aging was found in both sexes. In females F.Ct.Wi decreased (p < 0.02) with aging because of marrow expansion (p < 0.05). Furthermore, Ct.Po increased (p < 0.001) because of a decrease in W.Th (p < 0.01) and an increase in H.Ca.Dm (p < 0.001). In males the negative cortical bone balance with aging was exclusively caused by an increase in Ct.Po (p < 0.001) partially explained by an expanding H.Ca.Dm (p < 0.01). The On.Dm increased with aging (p < 0.01), but surprisingly, no fall in W.Th was observed. Reconstruction of the remodeling cycle did not reveal any significant difference between younger women and men. However, the activation frequency rose from 0.5 per year in premenopausal to 1.0 per year in postmenopausal women (p < 0.001), giving rise to a high turnover state, an increase in the remodeling space, and thereby the porosity in the cortical bone immediately after menopause. The present study has shown a reduction in cortical bone mass in elderly people, compared with younger, which may be explained by an age-related remodeling imbalance. This reduction is further increased in women in the postmenopausal state because of a postmenopausal accelerated bone turnover.